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Prenatal ambient air pollution exposure and small for gestational age birth in the Puget Sound Air Basin

机译：普吉特海湾空气盆地的产前环境空气污染暴露量小，适合胎龄儿

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摘要

Several studies have identified high concentrations of air pollution as harmful to the developing fetus, but few studies of traffic-derived air pollution and birth outcomes have been conducted in areas of low to moderate air pollution. We identified singleton live births between 1997 and 2005 (N = 367,046 births) in the Puget Sound Air Basin of Washington State. We estimated nitrogen dioxide (NO2) exposure using a land use regression model of traffic, PM2.5 exposure from the nearest community monitor, and proximity to highways/roadways for the residential location of all subjects. Logistic regression estimates of odds ratios (OR) of small for gestational age (SGA) and low birth weight (<2,500 g) among term births were calculated. We observed a modest association between SGA births with increasing quartile of first trimester NO2 exposure: second (OR = 1.01, 95 % confidence interval (CI) 0.97, 1.04), third (OR = 1.06, 95 % CI 1.03, 1.10), and fourth (OR = 1.08, 95 % CI 1.04, 1.12) (p trend <0.001). We did not observe an association between PM2.5 and SGA or low birth weight among term births. Our findings suggest that prenatal exposure to traffic-derived air pollutants has a modest effect on fetal growth in a region with low overall air pollutant concentrations. Given the modest associations, future studies in similar settings that maximize the opportunity to address potential residual confounding are needed.
机译：几项研究已经确定了高浓度的空气污染对发育中的胎儿有害，但是在中低度空气污染的地区，很少进行交通引起的空气污染和生育结果的研究。我们确定了华盛顿州普吉特海湾空气盆地在1997年至2005年之间的单胎活产（N = 367,046胎）。我们使用交通的土地利用回归模型，最近的社区监测者的PM2.5暴露以及所有受试者居住地的高速公路/道路的接近程度来估算二氧化氮（NO2）的暴露。计算了足月出生时胎龄（SGA）和低出生体重（<2,500 g）的比值比（OR）的Logistic回归估计。我们观察到SGA出生与孕早期NO2暴露四分位数增加之间的适度关联：第二（OR = 1.01，95％置信区间（CI）0.97，1.04），第三（OR = 1.06，95％CI 1.03，1.10），和第四（OR = 1.08，95％CI 1.04，1.12）（p趋势<0.001）。我们未观察到PM2.5与SGA之间的关联或足月出生时的低出生体重。我们的发现表明，在总体空气污染物浓度较低的地区，产前暴露于交通源性空气污染物对胎儿的生长有适度的影响。考虑到关联度不高，需要在相似环境中进行未来研究，以最大程度地解决潜在的残留混杂问题。

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  • 来源
    《Air quality, atmosphere & health》 |2013年第2期|455-463|共9页
  • 作者

    Sheela Sathyanarayana; Chuan Zhou; Carole B. Rudra; Tim Gould; Tim Larson; Jane Koenig; Catherine J. Karr;

  • 作者单位

    1.Department of Pediatrics University of Washington 2001 West 8th M/S CW 8-6 Seattle WA 98121 USA 2.Center for Child Health Behavior and Development Seattle Children’s Research Institute Seattle WA 98121 USA 5.Department of Environmental and Occupational Health Sciences University of Washington Seattle WA USA;

    2.Center for Child Health Behavior and Development Seattle Children’s Research Institute Seattle WA 98121 USA;

    3.Independent Health Buffalo NY 14221 USA;

    4.Civil and Environmental Engineering University of Washington Seattle WA USA;

    4.Civil and Environmental Engineering University of Washington Seattle WA USA 5.Department of Environmental and Occupational Health Sciences University of Washington Seattle WA USA;

    5.Department of Environmental and Occupational Health Sciences University of Washington Seattle WA USA;

    1.Department of Pediatrics University of Washington 2001 West 8th M/S CW 8-6 Seattle WA 98121 USA 5.Department of Environmental and Occupational Health Sciences University of Washington Seattle WA USA;

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  • 原文格式 PDF
  • 正文语种 eng
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  • 关键词

    Air pollution; Small for gestational age; Low birth weight; Traffic;

    机译：空气污染;胎龄小;体重低;交通;

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