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首页> 外文期刊>Alcohol and Alcoholism >Results from two pharmacotherapy trials show alcoholic smokers were more severely alcohol dependent but less prone to relapse than alcoholic non-smokers
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Results from two pharmacotherapy trials show alcoholic smokers were more severely alcohol dependent but less prone to relapse than alcoholic non-smokers

机译：两项药物疗法试验的结果显示，与不吸烟的吸烟者相比，酗酒的吸烟者对酒精的依赖性更高，但更不容易复发

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Aims: To assess the role of smoking on treatment outcome in quitting alcoholics on the background of the priming or coping hypothesis (Rohsenow et al., 1997). Methods: Data sets of placebo treated patients of the German phase III trial of naltrexone (Gastpar et al., 2002) and of acamprosate treated patients of a German phase IV trial Soyka et al., 2002) were reanalyzed. Differences between smoking and non-smoking alcoholics were evaluated using χ2-, t- or ANOVA-tests, relapse rates using survival techniques with Cox regression. Results: Smoking alcoholics differed significantly from non-smoking alcoholics regarding sociodemographic variables (e.g. more males, more often living alone) and severity indicators of alcoholism (e.g. quantity, onset, related problems). In the naltrexone study time to first relapse was significantly longer for smoking alcoholics compared to non-smoking alcoholics (hazard ratio = 2.26; P = 0.036). The same effect was seen in the acamprosate study (hazard ratio = 1.34; P = 0.015); estimated abstinence-rates after 24 weeks were 38% for smoking alcoholics compared to 28% for non-smoking alcoholics (P < 0.015). Conclusions: Smoking was significantly associated with better outcome in recovering alcoholics included in two pharmacotherapy trials. Although the underlying mechanisms remain unclear our findings are in favour of the coping hypothesis. The results challenge the validity of the dependence syndrome.
机译：目的：在引发或应对假设的背景下，评估吸烟对戒酒的治疗效果（Rohsenow等，1997）。方法：重新分析了纳曲酮的德国III期试验（Gastpar等，2002）和德国IV期试验Soyka等，2002用阿坎酸治疗的安慰剂治疗患者的数据集。使用χ 2 -，t-或ANOVA检验评估吸烟与不吸烟酒精中毒之间的差异，并使用生存技术和Cox回归评估复发率。结果：在社会人口统计学变量（例如，男性较多，更经常独自生活）和酗酒严重性指标（例如，数量，发作，相关问题）方面，吸烟酗酒者与非吸烟酗酒者存在显着差异。在纳曲酮研究中，吸烟者比非吸烟者首次复发的时间明显更长（危险比= 2.26； P = 0.036）。在阿坎酸研究中观察到了相同的效果（危险比= 1.34； P = 0.015）；吸烟者的估计戒酒率在24周后为38％，而非吸烟者为28％（P <0.015）。结论：两项药物治疗试验中，吸烟与酗酒者康复效果显着相关。尽管尚不清楚其基本机制，但我们的发现支持应对假说。结果挑战了依赖综合征的有效性。

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    《Alcohol and Alcoholism》 |2007年第3期|241-246|共6页
  • 作者

    Lutz G. Schmidt; and Michael N. Smolka;

  • 作者单位

    Department of Psychiatry Johannes Gutenberg-University Mainz Untere Zahlbacher Str. 8 55131 Mainz;

    Department of Psychiatry Technische Universität Dresden Fetscherstraße 74 01307 Dresden Germany;

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