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Speed of Sound and Apparent Molal Volume Approach to Study the Ion-Solvent Interactions in Pharmaceutically Important Liquid Systems

机译:声音和表观莫尔体积方法的速度研究药学上重要液体系统中的离子溶剂相互作用

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摘要

Presence of zinc ion and lactose in different pharmaceutical compositions have been inspired to investigate the ion-solvation and related interactions among the components in solution media. This study has been carried out by the measurements of ultrasonic velocity, viscosity and density for the binary solutions of zinc sulphate (ZnSO_4) in lactose-water mixed solvent systems at 303.15, 308.15, 313.15 K temperature and at atmospheric pressure. Different thermo-acoustic parameters such as isentropic compressibility, apparent molal volume, solvation number, free volume, internal pressure etc., have been evaluated from the measured values. All these parameters have been analyzed in the light of molecular interactions from their variations against concentration as well as temperature. Presence of ion-solvation and structure promoting nature of solute are the major findings in the present investigation. Besides, it also reveals that the ion-solvation decreases as the temperature increases.
机译:已经启发了不同药物组合物中锌离子和乳糖的存在,以研究溶液培养基中的组分之间的离子溶剂和相关相互作用。该研究已经通过测量超声速度,乳糖 - 水混合溶剂系统中的硫酸锌(ZnSO_4)的二元溶液的测量,在303.15,308.15,313.15k温度和大气压下进行。已经从测量值评估了不同热声学参数,例如熵压缩性,表观莫尔体积,溶剂化数,自由体积,内部压力等。已经根据与浓度的变化以及温度的分子相互作用来分析所有这些参数。溶质的离子溶剂化和结构的存在是本研究中的主要发现。此外,它还揭示了在温度升高时降低离子溶剂。

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