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首页> 外文期刊>American journal of applied sciences >Assessment of the Toxic Effects of Chitosan-Coated Magnetite Nanoparticles on Drosophila melanogaster
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Assessment of the Toxic Effects of Chitosan-Coated Magnetite Nanoparticles on Drosophila melanogaster

机译：评估壳聚糖涂层磁铁矿纳米粒子对果蝇的毒性作用

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摘要

Nanoparticles are a cause for concern because of their potential toxic effects on human health and the environment. The aim of this study was to assess the toxic effect of chitosan-coated magnetite nanoparticles (11.00±4.7 nm) on Drosophila melanogaster through the observation of hemolymph composition, DNA damage, larval survival and lifespan of flies. Chitosan-coated magnetite nanoparticles were synthesized by co-precipitation method. Drosophila larvaes and adults were exposed to 500 and 1000 ppm nanoparticles solution. After exposure, each type of larval hemocytes was recognized. Comet assay was performed to detect the DNA damage in the hemocytes. Also, the larval survival and lifespan of exposed flies were observed. Our results showed the toxic effect of the chitosan-coated magnetite nanoparticles through the increment of hemocytes, the emergence of lamellocytes, the presence of apoptotic hemocytes and the DNA damage detected by comet assay. In addition, nanoparticles produce decreasing of larval survival and shortening of the mean and maximum lifespan. The toxic effect the chitosan-coated magnetite nanoparticles is directly associated with 1000 ppm. No DNA damage was observed at 500 ppm.
机译：由于它们对人体健康和环境的潜在毒性影响，纳米粒子是令人担忧的。本研究的目的是通过观察血淋巴组成，DNA损伤，幼虫生存和寿命的苍蝇，评估壳聚糖涂层磁铁矿纳米粒子（11.00±4.7nm）的毒性作用。通过共沉淀法合成壳聚糖涂覆的磁铁矿纳米粒子。果蝇幼虫和成人暴露于500和1000ppm纳米颗粒溶液。暴露后，认识到每种类型的幼虫血细胞。进行彗星测定以检测血细胞中的DNA损伤。而且，观察到暴露苍蝇的幼虫存活和寿命。我们的结果表明，壳聚糖涂覆的磁铁矿纳米粒子通过血细胞增量，凋亡血细胞的出现以及彗星测定检测到的凋亡血细胞的存在和DNA损伤的毒性作用。此外，纳米颗粒产生幼虫存活率和缩短平均值和最大寿命。毒素涂覆的壳聚糖涂层磁铁矿纳米粒子与1000ppm直接相关。在500ppm下观察到没有DNA损伤。

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  • 来源
    《American journal of applied sciences》 |2020年第1期|204-213|共10页
  • 作者

    Doris Vela; Jonathan Rondal; Sofia Cardenas; Jose Gutierrez-Coronado; Eliza Jara; Alexis Debut; Fernanda Pilaquinga;

  • 作者单位

    Facultad de Ciencias Exactas y Naturales Laboratorio de Genetica Evolutiva Pontificia Universidad Catolica del Ecuador Quito Ecuador;

    Facultad de Ciencias Exactas y Naturales Laboratorio de Genetica Evolutiva Pontificia Universidad Catolica del Ecuador Quito Ecuador Departamento de Ciencias de la Vida y la Agricultura Universidad de las Fuerzas Armadas ESPE Sangolqui Ecuador;

    Facultad de Ciencias Exactas y Naturales Laboratorio de Nanotecnologia Pontificia Universidad Catolica del Ecuador Quito Ecuador;

    Universidad Autonoma de Madrid Madrid Spain;

    Facultad de Ciencias Exactas y Naturales Laboratorio de Nanotecnologia Pontificia Universidad Catolica del Ecuador Quito Ecuador;

    Centro de Nanociencias y Nanotecnologia Universidad de las Fuerzas Armadas ESPE Sangolqui Ecuador;

    Facultad de Ciencias Exactas y Naturales Laboratorio de Nanotecnologia Pontificia Universidad Catolica del Ecuador Quito Ecuador;

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  • 原文格式 PDF
  • 正文语种 eng
  • 中图分类
  • 关键词

    Comet Assay; Chitosan; Magnetite Nanoparticles; Hemolymph; Lifespan;

    机译：彗星测定;壳聚糖;磁铁矿纳米粒子;血淋巴;寿命;

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