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首页> 外文期刊>American Journal of Epidemiology >1.↵ International Agency for Research on Cancer. Monographs on the Evaluation of Carcinogenic Risks to Humans. Vol 60. Lyon, France: International Agency for Research on Cancer; 1994.
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1.↵ International Agency for Research on Cancer. Monographs on the Evaluation of Carcinogenic Risks to Humans. Vol 60. Lyon, France: International Agency for Research on Cancer; 1994.

机译：1.↵国际癌症研究机构。关于对人类致癌危险性评估的专着。第60卷。法国里昂：国际癌症研究机构。 1994年。

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摘要

Women with primary breast cancer are at increased risk of developing second primary breast cancer. Few studies have evaluated risk factors for the development of asynchronous contralateral breast cancer in women with breast cancer. In the Women's Environmental Cancer and Radiation Epidemiology Study (1985–2001), the roles of alcohol and smoking were examined in 708 women with asynchronous contralateral breast cancer (cases) compared with 1,399 women with unilateral breast cancer (controls). Cases and controls aged less than 55 years at first breast cancer diagnosis were identified from 5 population-based cancer registries in the United States and Denmark. Controls were matched to cases on birth year, diagnosis year, registry region, and race and countermatched on radiation treatment. Risk factor information was collected by telephone interview. Rate ratios and 95% confidence intervals were estimated by using conditional logistic regression. Ever regular drinking was associated with an increased risk of asynchronous contralateral breast cancer (rate ratio = 1.3, 95% confidence interval: 1.0, 1.6), and the risk increased with increasing duration (P = 0.03). Smoking was not related to asynchronous contralateral breast cancer. In this, the largest study of asynchronous contralateral breast cancer to date, alcohol is a risk factor for the disease, as it is for a first primary breast cancer.
机译：患有原发性乳腺癌的女性患第二发原发性乳腺癌的风险增加。很少有研究评估患有乳腺癌的女性异步对侧乳腺癌的危险因素。在《妇女环境癌症和辐射流行病学研究》（1985-2001年）中，对708名患有非对侧对侧乳腺癌的女性（病例）和1,399名单侧乳腺癌（对照）的女性进行了酒精和吸烟的检查。在美国和丹麦的5个基于人群的癌症登记处中，首次诊断为乳腺癌的年龄小于55岁的病例和对照被确定。对照与出生年，诊断年，登记地区和种族的病例相匹配，在放射治疗方面与对照相匹配。危险因素信息是通过电话采访收集的。率比和95％置信区间通过使用条件逻辑回归进行估算。经常喝酒会增加非对侧对侧乳腺癌的风险（比率= 1.3，95％置信区间：1.0、1.6），并且风险随着持续时间的增加而增加（P = 0.03）。吸烟与异步对侧乳腺癌无关。在这项迄今为止最大的异步对侧乳腺癌研究中，酒精是该疾病的危险因素，因为它是第一个原发性乳腺癌。

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