...
  • 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>AMERICAN JOURNAL OF HEMATOLOGY >Hemorheological alterations, decreased cerebral microvascular oxygenation and cerebral vasomotion compensation in sickle cell patients?
【24h】

Hemorheological alterations, decreased cerebral microvascular oxygenation and cerebral vasomotion compensation in sickle cell patients?

机译：镰状细胞患者的血液流变学改变，脑微血管氧合减少和脑血管运动补偿？

获取原文
获取原文并翻译 | 示例
   

获取外文期刊封面封底 >>

       
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

Sickle cell anemia (SS) is characterized by a reduced cerebral microvascular oxygen saturation (cerebral TOI), which is not associated with hemoglobin concentration. Cerebral TOI has never been studied in sickle cell-hemoglobin C disease (SC). We focused on the relationships between hemorheological alterations and cerebral TOI in sickle cell patients with no cerebral vasculopathy and on the usefulness of TOI variability to assess the cerebral vasomotion activity. The blood rheological profile, the level of cerebral TOI (spatial resolved spectroscopy) and the cerebral TOI variability, which reflects vasomotion activity, were compared between 20 healthy subjects (AA), 21 SC patients, and 21 SS patients. Cerebral TOI exhibited the following order: AA > SC > SS. The low cerebral TOI in SS patients was related to red blood cell aggregation and deformability properties. The cerebral TOI variability of SS and SC patients was increased above healthy values and vasomotion activity was negatively associated with the reduced cerebral TOI in SS patients. We demonstrated that (1) blood rheology could be involved in the reduced cerebral TOI in SS patients but not in SC patients; (2) vasomotion activity is increased in SS and SC patients to compensate for the reduced cerebral TOI. Am. J. Hematol. 2012. ? 2012 Wiley Periodicals, Inc.
机译：镰状细胞性贫血（SS）的特征是大脑微血管血氧饱和度降低（大脑TOI），这与血红蛋白浓度无关。从未在镰状细胞血红蛋白C病（SC）中研究过脑部TOI。我们重点研究了无脑血管病的镰状细胞患者血液流变学改变与脑部TOI之间的关系，以及TOI变异性对评估脑血管运动活性的有用性。比较了20名健康受试者（AA），21名SC患者和21名SS患者的血液流变学特征，脑部TOI（空间分辨光谱）水平和反映血管舒张活性的脑部TOI变异性。脑TOI表现出以下顺序：AA> SC> SS。 SS患者的脑部TOI较低与红细胞聚集和变形特性有关。 SS和SC患者的脑部TOI变异性高于健康值，而血管舒缩活性与SS患者的脑部TOI降低呈负相关。我们证明（1）血液流变学可能与SS患者的脑部TOI降低有关，而与SC患者无关。 （2）SS和SC患者的血管舒张活动增加，以弥补脑部TOI降低。上午。 J. Hematol。 2012。 2012 Wiley期刊公司

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号