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首页> 外文期刊>American Journal of Neuroradiology >MR Imaging Detection of Cerebral Microbleeds: Effect of Susceptibility-Weighted Imaging, Section Thickness, and Field Strength
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MR Imaging Detection of Cerebral Microbleeds: Effect of Susceptibility-Weighted Imaging, Section Thickness, and Field Strength

机译：MR成像检测脑微出血：磁化加权成像，切片厚度和场强的影响

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BACKGROUND AND PURPOSE: The emergence of cerebral microbleeds (CMB) as common MR imaging findings raises the question of how MR imaging parameters influence CMB detection. To evaluate the effects of modified gradient recalled-echo (GRE) MR imaging methods, we performed an analysis of sequence, section thickness, and field strength on CMB imaging properties and detection in subjects with cerebral amyloid angiopathy (CAA), a condition associated with microhemorrhage. MATERIALS AND METHODS: Multiple MR images were obtained from subjects with probable CAA, with varying sequences (GRE versus susceptibility-weighted imaging [SWI]), section thicknesses (1.2–1.5 versus 5 mm), and magnetic field strengths (1.5T versus 3T). Individual CMB were manually identified and analyzed for contrast index (lesion intensity normalized to normal-appearing white matter signal intensity) and diameter. CMB counts were compared between 1.5T thick-section GRE and thin-section SWI for 3 subjects who underwent both protocols in the same scanning session. RESULTS: With other parameters constant, use of SWI, thinner sections, and a higher field strength yielded medium-to-large gains in CMB contrast index (CI; Cohen d 0.71–1.87). SWI was also associated with small increases in CMB diameter (Cohen d <0.3). Conventional thick-section GRE identified only 33% of CMB (103 of 310) seen on thin-section SWI. Lesions prospectively identified on GRE had significantly greater CI and diameter measured on the GRE image than those not prospectively identified. CONCLUSIONS: The examined alternatives to conventional GRE MR imaging yield substantially improved CMB contrast and sensitivity for detection. Future studies based on these techniques will most likely yield even higher prevalence estimates for CMB.
机译：背景与目的：脑微出血（sMB）（CMB）的出现是常见的MR影像学发现，提出了 MR成像参数如何影响CMB检测的问题。为了评估改进的梯度回波回波（GRE）MR成像 方法的 效果，我们对序列，截面厚度， 和视野进行了分析。 与微出血相关的脑淀粉样血管病（CAA）受试者对CMB成像特性的检测强度和检测。 材料与方法：多重MR图像是从具有可能CAA的 受试者获得的，具有不同的序列（GRE与 药敏加权成像[SWI]），切片厚度 （1.2– 1.5毫米和5毫米），以及磁场强度（1.5T 对比3T）。手动识别各个CMB，并进行 对比指数（病变强度标准化为正常出现的 白质信号强度）和直径。比较了在同一扫描 会话中同时接受两种方案的3名受试者的CMB计数 与1.5T厚截面GRE和薄截面SWI 之间的比较。 结果：在其他参数不变的情况下，使用SWI，更薄的 部分和更高的场强在CMB对比度中获得了中到大的 增益。指数（CI； Cohen d 0.71–1.87）。 SWI 也与CMB直径的小幅增加相关（Cohen d <0.3）。常规的厚截面GRE只能在薄截面SWI上识别出CMB的33％ （310中的103）。在GRE图像上预期的 病变在GRE图像上测量的CI和直径 明显大于未在预期中发现的病变。 结论：经检查的常规替代方法GRE MR 成像可显着提高CMB对比度和检测灵敏度。基于这些技术的未来研究将 最有可能产生更高的CMB患病率估计值。

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  • 来源
    《American Journal of Neuroradiology》 |2009年第2期|338-343|共6页
  • 作者

    R.N.K. Nandigam; A. Viswanathan; P. Delgado; M.E. Skehan; E.E. Smith; J. Rosand; S.M. Greenberg; B.C. Dickerson;

  • 作者单位

    Hemorrhagic Stroke Research Program, Massachusetts General Hospital and Harvard Medical School, Boston, Mass;

    Hemorrhagic Stroke Research Program, Massachusetts General Hospital and Harvard Medical School, Boston, Mass;

    Hemorrhagic Stroke Research Program, Massachusetts General Hospital and Harvard Medical School, Boston, Mass;

    Hemorrhagic Stroke Research Program, Massachusetts General Hospital and Harvard Medical School, Boston, Mass;

    Hemorrhagic Stroke Research Program, Massachusetts General Hospital and Harvard Medical School, Boston, Mass;

    Hemorrhagic Stroke Research Program, Massachusetts General Hospital and Harvard Medical School, Boston, Mass;

    Hemorrhagic Stroke Research Program, Massachusetts General Hospital and Harvard Medical School, Boston, Mass;

    Alzheimer's Disease Research Center, Department of Neurology, Massachusetts General Hospital and Harvard Medical School, Boston, Mass|Athinoula A. Martinos Center for Biomedical Imaging, Charlestown, Mass;

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