...
  • 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>American Journal of Neuroradiology >Effects of Donepezil on Cortical Activation in Mild Cognitive Impairment: A Pilot Double-Blind Placebo-Controlled Trial Using Functional MR Imaging
【24h】

Effects of Donepezil on Cortical Activation in Mild Cognitive Impairment: A Pilot Double-Blind Placebo-Controlled Trial Using Functional MR Imaging

机译：多奈哌齐对轻度认知障碍中皮层激活的影响：使用功能性MR成像的双盲安慰剂对照试验

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

BACKGROUND AND PURPOSE: Cholinesterase-inhibitor therapy is approved for treatment of Alzheimer disease; however, application in patients with mild cognitive impairment (MCI) is still under active investigation. The purpose of this study was to determine the effect of such therapy on the neural substrates underlying memory processing in subjects with MCI by using functional MR imaging (fMRI). MATERIALS AND METHODS: Thirteen subjects with MCI (mean age, 68 ± 6.9 years) enrolled in a multicenter double-blind placebo-controlled trial testing the clinical efficacy of the cholinesterase-inhibitor, donepezil, were studied with fMRI at baseline and following 12 or 24 weeks of therapy (single-site pilot study). The cognitive paradigm was delayed-response visual memory for novel faces. Within-group 1-sample t tests were performed on the donepezil and placebo groups at baseline and at follow-up. A repeated-measures analysis of variance design was used to look for a Treatment Group x Time interaction showing a significant donepezil- but not placebo-related change in blood oxygen level–dependent response during the course of the study. RESULTS: At baseline, both groups showed multiple areas of activation, including the bilateral dorsolateral prefrontal cortex, fusiform gyrus, and anterior cingulate cortex. On follow-up, the placebo group demonstrated a decreased extent of dorsolateral prefrontal activation, whereas the donepezil group demonstrated an increased extent of activation in the ventrolateral prefrontal cortex. Interaction demonstrated significant donepezil- but not placebo-related change in the left inferior frontal gyrus. CONCLUSIONS: Despite the limitations inherent to a pilot study of a small sample, our results point to specific cortical substrates underlying the actions of donepezil, which can be tested in future studies.
机译：背景与目的：胆碱酯酶抑制剂治疗被批准用于治疗阿尔茨海默氏病； 但是，在轻度认知障碍（MCI）患者中的应用 仍在 积极调查中。这项研究的目的是通过功能性MR 成像来确定 这种疗法对MCI患者中 记忆处理基础的神经基质的影响（fMRI）。 材料和方法：十三名MCI患者（平均年龄， 68±6.9岁）参加了多中心双盲 安慰剂研究基线和治疗12或24周后用fMRI 研究了 胆碱酯酶抑制剂多奈哌齐的临床疗效的对照试验（单部位 试点研究）。认知范式是新面孔的延迟响应视觉 记忆。在基线和随访时对多奈哌齐和安慰剂组进行了组内1样本t检验 。 使用方差设计的重复测量分析来< sup> 寻找一个治疗组x时间交互作用，显示在治疗过程中与血氧水平相关的 响应出现明显的 donepezil-而非安慰剂相关变化结果：在基线时，两组均显示多个激活区域，包括双侧背外侧前额叶皮层，梭形 回和前扣带皮层。随访时，安慰剂 组的背外侧前额叶 活化程度降低，而多奈哌齐组的 活化程度升高。结论：尽管存在固有的局限性，但交互作用显示左下额回的明显的多奈哌齐相关但与安慰剂相关的 没有变化。 结论：尽管存在固有的局限性一项小样本的初步研究 ，我们的结果指出了在多奈哌齐作用基础上的特定皮质底物 ，可以在 未来研究中对其进行测试。

著录项

  • 来源
    《American Journal of Neuroradiology》 |2009年第2期|411-416|共6页
  • 作者

    J.R. Petrella; S.E. Prince; S. Krishnan; H. Husn; L. Kelley; P.M. Doraiswamy;

  • 作者单位

    Department of Radiology, Alzheimer's Disease Imaging Research Laboratory and Brain Imaging and Analysis Center, Duke University Medical Center, Duke University, Durham, NC;

    Department of Radiology, Alzheimer's Disease Imaging Research Laboratory and Brain Imaging and Analysis Center, Duke University Medical Center, Duke University, Durham, NC;

    Department of Radiology, Alzheimer's Disease Imaging Research Laboratory and Brain Imaging and Analysis Center, Duke University Medical Center, Duke University, Durham, NC;

    Departments of Psychiatry and Medicine (Geriatrics), Duke University Medical Center, Duke University, Durham, NC;

    Departments of Psychiatry and Medicine (Geriatrics), Duke University Medical Center, Duke University, Durham, NC;

    Departments of Psychiatry and Medicine (Geriatrics), Duke University Medical Center, Duke University, Durham, NC|Center for Study of Aging, Duke University Medical Center, Duke University, Durham, NC;

  • 收录信息
  • 原文格式 PDF
  • 正文语种 eng
  • 中图分类
  • 关键词

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号