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首页> 外文期刊>American Journal of Neuroradiology >Simultaneous Measurement of Arterial Transit Time, Arterial Blood Volume, and Cerebral Blood Flow Using Arterial Spin-Labeling in Patients with Alzheimer Disease
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Simultaneous Measurement of Arterial Transit Time, Arterial Blood Volume, and Cerebral Blood Flow Using Arterial Spin-Labeling in Patients with Alzheimer Disease

机译：使用阿尔茨海默氏病患者的动脉自旋标签同时测量动脉通过时间，动脉血容量和脑血流量

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BACKGROUND AND PURPOSE: Cerebral hemodynamics abnormality in Alzheimer disease (AD) is not fully understood. Our aim was to determine whether regional hypoperfusion due to AD is associated with abnormalities in regional arterial blood volume (rABV) and regional arterial transit time (rATT) as measured by quantitative arterial spin-labeling (ASL) with multiple-delay time sampling. MATERIALS AND METHODS: Nineteen patients with AD (9 men and 10 women; mean age, 74.5 ± 8.6 years) and 22 cognitively healthy control subjects (11 men and 11 women; mean age, 72.8 ± 6.8 years) were studied by using a quantitative ASL method with multiple-delay time sampling. From the ASL data, maps of regional cerebral blood flow (rCBF), rABV, and rATT were generated. A region of hypoperfusion due to AD was determined by statistical parametric mapping (SPM) analysis. Mean rCBF, rABV, and rATT values within the hypoperfused region were compared between the AD and control groups. RESULTS: Despite the significantly lower rCBF (P = .0004) in patients with AD (27.8 ± 7.1 mL/100 g/min) in comparison with control subjects (36.7 ± 6.3 mL/100 g/min), no significant difference in rATT was observed between the control (0.48 ± 0.09 seconds) and AD (0.47 ± 0.10 seconds) groups. Mean rABV was lower in the AD group (0.22 ± 0.10%) than in the control group (0.27 ± 0.12%), though the difference did not reach the level of statistical significance. CONCLUSIONS: Our results revealed that regional hypoperfusion in AD is not associated with rATT prolongation, suggesting that the mechanism of hypoperfusion is distinct from that in cerebrovascular diseases.
机译：背景与目的： 阿尔茨海默病（AD）的脑血流动力学异常尚未完全了解。我们的目的是 确定是否由于AD引起的区域灌注不足与区域动脉血容量（rABV） 和区域动脉通过时间的异常有关（ rATT），采用定量 动脉自旋标记（ASL）进行多次延迟采样。 材料和方法：19例AD患者（9名男性， < / sup> 10名女性；平均年龄74.5±8.6岁）和22名认知健康控制受试者（11名男性和11名女性；平均年龄72.8 ±6.8岁）通过使用定量ASL 方法和多延迟时间采样进行研究。从ASL数据中，生成了局部脑血流量（rCBF），rABV和rATT 的 图。通过统计参数映射（SPM）分析确定了AD引起的灌注不足区域。比较了AD组和对照组的低灌注区域内的平均rCBF， rABV和rATT值。 结果：尽管rCBF明显较低（ P = 0.0004） AD患者（27.8±7.1 mL / 100 g / min）与对照组（36.7±6.3 mL / 100 g / min）比较，对照组（0.48± 0.09秒）和AD（0.47±0.10秒）组之间在rATT上未观察到显着的 差异。尽管差异 ，但AD组的均值 rABV低于对照组的（0.22±0.10％）（0.27±0.12％）。结论未达到统计学显着性水平。结论：我们的研究结果表明，AD中的区域性灌注不足与rATT延长无关，提示 灌注不足的机制与脑血管疾病不同。

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  • 来源
    《American Journal of Neuroradiology》 |2009年第7期|1388-1393|共6页
  • 作者

    T. Yoshiura; A. Hiwatashi; K. Yamashita; Y. Ohyagi; A. Monji; Y. Takayama; E. Nagao; H. Kamano; T. Noguchi; H. Honda;

  • 作者单位

    Department of Clinical Radiology, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan;

    Department of Clinical Radiology, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan;

    Department of Clinical Radiology, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan;

    Department of Neurology, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan;

    Department of Clinical Radiology, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan|Department of Neuropsychiatry, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan;

    Department of Clinical Radiology, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan;

    Department of Clinical Radiology, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan;

    Department of Clinical Radiology, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan;

    Department of Clinical Radiology, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan;

    Department of Clinical Radiology, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan;

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