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首页> 外文期刊>American Journal of Neuroradiology >MR Imaging Assessment of Brain and Cervical Cord Damage in Patients with Neuroborreliosis
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MR Imaging Assessment of Brain and Cervical Cord Damage in Patients with Neuroborreliosis

机译：MR影像学评估神经衰弱患者脑和颈髓损伤

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BACKGROUND AND PURPOSE: Neuroborreliosis is frequently indistinguishable from multiple sclerosis (MS) on both clinical and radiologic grounds. By using MR imaging, we assessed "occult" brain white matter (WM), brain gray matter (GM), and cervical cord damage in patients with neuroborreliosis in an attempt to achieve a more accurate picture of tissue damage in these patients, which might contribute to the diagnostic work-up. METHODS: We studied 20 patients with neuroborreliosis and 11 sex- and age-matched control subjects. In all subjects, we acquired dual echo, T1-weighted, diffusion tensor (DT) and magnetization transfer (MT) MR imaging scans of the brain and fast short- inversion recovery and MT MR imaging scans of the cervical cord. T2-visible lesion load was measured by using a local thresholding segmentation technique. Mean diffusivity and fractional anisotropy histograms of the brain and cervical cord MT ratio histograms were produced. Normalized brain volumes (NBV) were measured by using SIENAx. RESULTS: Brain T2-visible lesions were detected in 12 patients, whereas no occult damage in the normal-appearing WM and GM was disclosed by using MT and DT MR imaging. No macroscopic lesions were found in the cervical cord, which was also spared by occult pathology. NBV did not differ between patients with neuroborreliosis and control subjects. CONCLUSION: This study shows that, contrary to what happens in MS, occult brain tissue damage and cervical cord pathology are not frequent findings in patients with neuroborreliosis. These observations might be useful in the diagnostic work-up of patients with neuroborreliosis and T2 brain lesions undistinguishable from those of MS.
机译：背景与目的：神经硼化病在临床和放射学上都与多发性硬化症（MS）经常无法区分 。通过使用MR成像，我们评估了神经性硼尿病患者的“隐匿性”脑白质（WM），脑灰质（GM）和颈索损伤 ，以试图在这些患者中获得了 更加准确的组织损伤图，这可能有助于诊断检查。 方法：我们研究了20例神经衰弱症和11名与年龄和年龄匹配的对照受试者。在所有受试者中，我们获得了大脑的 双回波，T1加权，弥散张量（DT）和磁化 传递（MT）MR成像扫描以及快速的 > 颈椎反转恢复和MT MR成像扫描。 T2可见病变负荷通过局部阈值 分段技术进行测量。产生了大脑的平均扩散率和分数各向异性 直方图，以及子宫颈MT比率直方图 。使用SIENAx测量标准化的脑容量（NBV）。 结果：1​​2例患者发现了脑T2可见病变，没有隐匿性损害。通过MT和DT MR成像显示了正常出现的WM和GM中的s 。在子宫颈线中未发现肉眼可见的 ，也可通过隐匿性 病理学幸免。结论：这项研究表明，与MS中发生的 相反，隐匿性脑组织与NBV并无差异。损伤和颈椎病理学 在神经性硼尿病患者中并不常见。 这些观察结果可能对神经性硼尿病患者的诊断检查 有用和T2脑部损伤与MS的区别不大。

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    《American Journal of Neuroradiology》 |2006年第4期|00000892-00000894|共3页
  • 作者

    F. Agosta; M.A. Rocca; B. Benedetti; R. Capra; C. Cordioli; M. Filippi;

  • 作者单位

    Neuroimaging Research Unit, Department of Neurology, Scientific Institute and University Ospedale San Raffaele, Milan, Italy;

    Neuroimaging Research Unit, Department of Neurology, Scientific Institute and University Ospedale San Raffaele, Milan, Italy;

    Neuroimaging Research Unit, Department of Neurology, Scientific Institute and University Ospedale San Raffaele, Milan, Italy;

    Multiple Sclerosis Center, Spedali Civili, Brescia, Italy;

    Multiple Sclerosis Center, Spedali Civili, Brescia, Italy;

    Neuroimaging Research Unit, Department of Neurology, Scientific Institute and University Ospedale San Raffaele, Milan, Italy;

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