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首页> 外文期刊>American Journal of Neuroradiology >Temporal Lobe Morphology in Normal Aging and Traumatic Brain Injury
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Temporal Lobe Morphology in Normal Aging and Traumatic Brain Injury

机译：正常衰老和颅脑损伤中的颞叶形态

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BACKGROUND AND PURPOSE: Little is known regarding changes in the temporal lobe associated with traumatic brain injury (TBI) in early-to-mid adulthood. We report on two quantitative MR studies: study 1 addressed age-related changes of the temporal lobe in subjects aged 16–72 years; information obtained in this study provided a normative database for comparison with findings in 118 patients with TBI who were included in study 2. We expected stable morphology in healthy subjects and trauma-related atrophy in patients with TBI. METHODS: MR multispectral tissue segmentation was used to calculate bilateral temporal lobe gyrus and sulcus, sylvian fissure CSF, hippocampus, and temporal horn volumes and to measure the white matter (WM) temporal stem. RESULTS: With normal aging, gyral volume remained stable, decreasing approximately 0.26% per year (total, 11%). Sulcal CSF volume doubled. Hippocampal volume decreased (minimally, significantly); temporal horn volume increased (not significantly) and was minimally related to hippocampal volume. WM measurements were constant. Trauma changed morphology; WM measures decreased. Gyral volumes were not different between the groups. In TBI, CSF volume increased significantly, was most related to reduced WM measurements, and was relatively independent of gyral volume. Temporal horn dilatation was related more to WM atrophy than to hippocampal atrophy. In TBI, subarachnoid sulcal and temporal horn CSF volumes were most related to WM atrophy, which was relatively independent of gyral volume; gyral and hippocampal volumes and WM measures were related to memory performance. CONCLUSION: Age-related changes cause minimal temporal lobe gyral, hippocampal, temporal horn, and WM atrophy. Only subarachnoid sulcal CSF volume changed robustly. Trauma produced disproportionate WM loss associated with increased temporal horn and sulcal CSF volumes; it caused substantial hippocampal atrophy, which was related to memory impairment. Gyral volume did not decrease, although it was related to memory performance.
机译：背景与目的：关于成年早期至中期的与脑外伤（TBI）相关的颞叶变化的知之甚少。我们报告了两个定量的MR 研究：研究1解决了16-72岁受试者颞叶的与年龄相关的变化；在本研究中获得的信息 提供了一个规范数据库，用于与被纳入研究 2的118例TBI患者的 结果进行比较。我们期望健康受试者的形态稳定，并伴有TBI患者创伤相关的 萎缩。 方法：采用MR多光谱组织分割法来计算叶回和沟，侧裂CSF， 海马和颞角体积，并测量白色 （WM）颞干。 结果：在正常衰老的情况下，回旋体积保持稳定，每年下降 约0.26％（总计11％）。颅脑脊液体积 增加了一倍。海马体积减少（最小，显着）； 颞角体积增加（不显着），与海马体积最小相关。 WM测量值是恒定的。 创伤改变了形态。仓库管理措施减少。两组之间的回旋容积 没有区别。在TBI中，脑脊液体积显着增加 ，与减少WM测量值最相关， ，并且与回旋体积无关。颞角 扩张与WM萎缩的关系更多，而不是与海马 萎缩有关。在TBI中，蛛网膜下腔和颞角CSF体积与WM萎缩最相关，而WM萎缩与回旋体积无关。结论：与年龄相关的变化导致最小的颞叶stempal角，海马体，颞角等。与年龄相关的记忆力与记忆力有关。 结论和WM萎缩。只有蛛网膜下腔 CSF体积变化很大。创伤导致不合比例的 WM丢失，与颞角和龈沟CSF 体积增加有关；它导致大量海马萎缩，这与记忆障碍有关。 陀螺体积没有减少， 尽管与记忆性能有关。

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  • 来源
    《American Journal of Neuroradiology》 |2002年第2期|255-266|共12页
  • 作者

    Erin D. Bigler; Carol V. Andersob; Duane D. Blatter;

  • 作者单位

    Department of Psychology, Brigham Young University, Provo, Utah|LDS Hospital, Provo, Utah|University of Utah, Provo, Utah;

    Department of Psychology, Brigham Young University, Provo, Utah|Department of Neuroscience, Brigham Young University, Provo, Utah;

    LDS Hospital, Provo, Utah;

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