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首页> 外文期刊>American Journal of Neuroradiology >Diffusion Tensor MR Imaging of High-Grade Cerebral Gliomas
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Diffusion Tensor MR Imaging of High-Grade Cerebral Gliomas

机译：高级别脑胶质瘤的扩散张量MR成像

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BACKGROUND AND PURPOSE: Optimizing high-grade glioma treatment requires the delineation of edematous and normal brain from tumor, perhaps by using potential differences in the absolute diffusion parameters of water. Our purpose was to determine whether mean diffusivity and diffusion anisotropic MR imaging data help in this differentiation. METHODS: Nine patients with high-grade cerebral glioblastoma underwent contrast-enhanced structural and diffusion tensor MR imaging before therapy. Tumor, edematous brain, and apparently normal white matter regions were determined on T2-weighted and contrast-enhanced T1-weighted structural images. Fractional anisotropy (FA) and were measured in each tissue type. Differences in these values among the tissue types were assessed with a standard analysis of variance. RESULTS: was highest in the necrotic tumor core (1825.38 ±404.06) x 10-6 mm2/s, followed by edematous brain (1411.23 ± 322.31) x 10-6 mm2/s, enhancing tumor core (1308.67 ± 292.50) x 10-6 mm2/s, enhancing tumor margin (1229.80 ± 206.80) x 10-6 mm2/s, and normal brain (731.53 ± 35.21) x 10-6 mm2/s. FA was highest in normal brain (0.47 ± 0.08) and lowest in the necrotic core (0.09 ± 0.03). was significantly different in enhancing tumor margins and edematous brain in all patients; FA was significantly different in only seven. These values were significantly different from those of normal brain in all cases in which they were measurable. CONCLUSION: values can be used to differentiate normal white matter, edematous brain, and enhancing tumor margins. Diffusion anisotropic data added no benefit to tissue differentiation. Further studies are required to determine if a value that corresponds to the limit of tumor invasion can be identified.
机译：背景与目的：优化高级神经胶质瘤治疗 需要从 肿瘤中划定水肿和正常大脑的轮廓，也许是通过使用绝对 中的潜在差异水的扩散参数。我们的目的是确定 平均弥散度和弥散各向异性MR成像 数据是否有助于这种分化。 方法：9例高级脑胶质母细胞瘤患者在治疗前对 进行对比增强的结构和扩散张量 MR成像。在T2加权和 对比度增强的T1加权结构图像上确定肿瘤，脑水肿和 正常白质区域。在每种组织类型中均测量分数 各向异性（FA）。通过标准方差分析评估组织类型之间这些值的差异。结果：在坏死肿瘤核心中最高（1825.38± 404.06） x 10 -6 mm 2 / s，随后是水肿的大脑（1411.23± 322.31）x 10 -6 mm 2 / s，增强肿瘤核心（1308.67± 292.50）x 10 -6 mm 2 / s，增强肿瘤切缘（1229.80± 206.80）x 10 -6 mm 2 / s，大脑正常（731.53±35.21） x 10 -6 mm 2 / s。 FA在正常脑中最高（0.47± 0.08），在坏死核心中最低（0.09±0.03）。 在增加肿瘤切缘和 方面有显着差异所有患者的大脑水肿； FA仅在七个方面显着不同 。在所有可测量的情况下，这些值均与正常人的 显着不同。 结论：这些值可用于区分正常白人 物质，脑水肿和增强肿瘤边缘。扩散 各向异性数据对组织分化没有好处。 需要进一步的研究来确定 对应于肿瘤浸润极限的值是否可以已识别。

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    《American Journal of Neuroradiology》 |2002年第4期|520-527|共8页
  • 作者

    Saurabh Sinha; Mark E. Bastin; Ian R. Whittle; Joanna M. Wardlaw;

  • 作者单位

    Department of Clinical Neurosciences, University of Edinburgh, Western General Hospital, Crewe Road, Scotland;

    Department of Medical and Radiological Sciences (Medical Physics), University of Edinburgh, Western General Hospital, Crewe Road, Scotland;

    Department of Clinical Neurosciences, University of Edinburgh, Western General Hospital, Crewe Road, Scotland;

    Department of Clinical Neurosciences, University of Edinburgh, Western General Hospital, Crewe Road, Scotland;

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