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首页> 外文期刊>American Journal of Neuroradiology >Quantification and Reproducibility of Tracking Cortical Extent of Activation by Use of Functional MR Imaging and Magnetoencephalography
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Quantification and Reproducibility of Tracking Cortical Extent of Activation by Use of Functional MR Imaging and Magnetoencephalography

机译：通过使用功能性MR成像和脑磁图跟踪皮质激活程度的量化和可重复性。

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BACKGROUND AND PURPOSE: Functional MR imaging and magnetoencephalography are commonly used to study normal cortical sensory and cognitive processing as well as a variety of disease states. The usefulness of these techniques is dependent on the reproducibility and sensitivity to change of derived measures of brain function. The purpose of this study was to compare the efficacy of functional MR imaging and magnetoencephalography as measures of the extent of cortical activity in response to a graded stimulus. METHODS: Five participants underwent functional MR imaging and magnetoencephalography involving stimulation of one, two, three, and four digits of the left hand. Measurements of activation were repeated three times per participant. The cortical extent of activation was assessed for functional MR imaging by observing the number of "activated" pixels and the "amount of activation": the product of the number of activated pixels and the mean signal change. Activation was quantified for magnetoencephalography as the magnitude of the evoked magnetic field peak and as the strength of the modeled current source, Q. RESULTS: For functional MR imaging, the number of activated pixels tended to increase with the increasing number of stimulated digits. High intra- and interparticipant variability (66% and 85% variation, respectively) did not, however, allow statistical resolution of this trend. The amount of activation was similarly variable (interparticipant, 89%). Magnetoencephalography was more robust regarding quantification. The evoked field amplitude varied linearly with the number of digits stimulated; intra- and interparticipant variability was 18% and 41%, respectively, permitting resolution of significant differences between any combination of stimulated digits, except two versus three (P < .05). CONCLUSION: Although functional MR imaging and magnetoencephalography show measurable evoked responses with somatosensory stimulation, in this study, functional MR imaging did not permit robust quantification of increasing cortical areas of activation.
机译：背景与目的：功能性磁共振成像和脑磁图 通常用于研究正常的皮层感觉和认知过程以及多种疾病状态。这些技术的有效性 取决于对脑功能衍生指标变化的可重复性和 敏感性。 本研究的目的是比较功能磁共振成像和脑磁图测量对分级刺激反应皮质活动程度的功效。方法：五名参与者进行了功能性MR成像和 脑磁图，涉及刺激左手的一，二，三， 和四位数。每个参与者重复测量激活 3次。通过观察 “被激活”像素的数量和“激活量”： 来评估皮质的激活程度 以进行功能性MR成像。激活像素数与平均信号 变化的乘积。磁脑电图的激活量化为 ，即诱发的磁场峰值的大小和建模电流源的 强度。Q. 结果：对于在功能性MR成像中，激活的 像素的数量往往随着受刺激的 位数的增加而增加。参与者之间和参与者之间的高变异性（分别为66％和 85％变异）不允许这种趋势的统计 解决方案。激活量类似地 可变（参与者间，89％）。磁脑电图在量化方面更强健 。诱发的场振幅 随受刺激的位数而线性变化；内部 和参与者间的变异性分别为18％和41％， 允许分辨任何受刺激的数字 组合之间的显着差异，但两个与结论（3）（P <.05）。 结论：尽管功能性MR成像和脑磁图 表现出可测量的诱发的体感刺激反应， 在这项研究中，功能性MR成像无法对增强的皮质激活区域进行可靠的量化 。

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    《American Journal of Neuroradiology》 |2000年第8期|1377-1387|共11页
  • 作者

    Timothy P.L. Roberts; Elizabeth A. Disbrow; Heidi C. Roberts; Howard A. Rowley;

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    From the Biomagnetic Imaging Laboratory, Department of Radiology, University of California, San Francisco, San Francisco, CA.;

    From the Biomagnetic Imaging Laboratory, Department of Radiology, University of California, San Francisco, San Francisco, CA.;

    From the Biomagnetic Imaging Laboratory, Department of Radiology, University of California, San Francisco, San Francisco, CA.;

    From the Biomagnetic Imaging Laboratory, Department of Radiology, University of California, San Francisco, San Francisco, CA.;

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