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首页> 外文期刊>American Journal of Neuroradiology >Ex Vivo Study of the Physical Effect of Coils on Pressure and Flow Dynamics in Experimental Aneurysms
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Ex Vivo Study of the Physical Effect of Coils on Pressure and Flow Dynamics in Experimental Aneurysms

机译：线圈对实验性动脉瘤中压力和流动动力学的物理影响的体内研究

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BACKGROUND AND PURPOSE: Recent experimental studies and a few case reports reveal that coiling may not lead to permanent occlusion of aneurysms by an organized thrombus. Therefore, biologic long-term prognosis seems to be doubtful, and the physical effect of coils may be important. The purpose of this study was to investigate the physical effect of coils on pressure and flow dynamics in aneurysms. METHODS: Bifurcation aneurysms were created in eight rabbits, explanted after 3 weeks, and tested in a model with pulsatile perfusion with 0.9% saline and heparinized blood. Before and after densely packing with coils, systemic and intraaneurysmal pressure, aneurysmal pulsation, and impact measurements were recorded. RESULTS: The peak and shape of the pressure waves in the aneurysm and in the delivery system were not significantly different before and after coiling. Under physiological intraaneurysmal pressure (while being perfused with saline), significant reduction (P = .022) of aneurysmal wall pulsation after coil embolization was noted. Overall, the aneurysmal impact on surrounding structures was statistically unchanged after coiling. However, in a few cases, after coil embolization, the observed increase of impact was more than doubled compared with the original values before coiling. CONCLUSION: Coils do not physically affect intraaneurysmal pressure. After coiling, there is no significant reduction of flow rates through the aneurysm and no reduction of aneurysmal impact, but aneurysmal wall pulsation may be decreased.
机译：背景与目的：最近的实验研究和一些 病例报告显示，盘绕可能不会导致有组织的血栓永久性阻塞动脉瘤。因此，生物学 的长期预后似乎令人怀疑，而线圈 的物理作用可能很重要。这项研究的目的是研究 线圈对 动脉瘤中压力和血流动力学的物理影响。 方法：在八个动脉中创建了分叉动脉瘤。兔， 3周后移出，并在具有0.9％盐水和肝素化血的搏动性 灌注模型中进行测试。记录 之前和之后的 ，记录 的全身和动脉瘤内 压力，动脉瘤脉动和冲击测量值。 结果：动脉瘤 和分娩系统中的压力波的峰和形状在卷绕前后无明显差异。在生理性动脉瘤内 压力下（灌注生理盐水），发现线圈栓塞后 （P = .022）显着降低了动脉瘤壁搏动 。总体而言，盘绕后动脉瘤对周围结构 的影响在统计学上没有变化。但是，在少数 情况下，在线圈栓塞后，观察到的冲击 的增加是与 卷取之前的原始值的两倍以上。结论：盘管不会对动脉瘤内压力产生物理影响。 盘绕后，通过动脉瘤的流速没有显着降低 ，也没有降低动脉瘤的影响， ，但动脉瘤壁搏动可能减少。

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    《American Journal of Neuroradiology》 |2000年第8期|1532-1536|共5页
  • 作者

    Hans G. Boecher-Schwarz; Kurt Ringel; Laszlo Kopacz; Axel Heimann; Oliver Kempski;

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    From the Departments of Neurosurgery (H.G.B.-S.) and Neuroradiology (K.R.), University Hospital, and the Institut of Neurosurgical Pathophysiology (L.K., A.H., O.K.), University of Mainz, Mainz, Germany.;

    From the Departments of Neurosurgery (H.G.B.-S.) and Neuroradiology (K.R.), University Hospital, and the Institut of Neurosurgical Pathophysiology (L.K., A.H., O.K.), University of Mainz, Mainz, Germany.;

    From the Departments of Neurosurgery (H.G.B.-S.) and Neuroradiology (K.R.), University Hospital, and the Institut of Neurosurgical Pathophysiology (L.K., A.H., O.K.), University of Mainz, Mainz, Germany.;

    From the Departments of Neurosurgery (H.G.B.-S.) and Neuroradiology (K.R.), University Hospital, and the Institut of Neurosurgical Pathophysiology (L.K., A.H., O.K.), University of Mainz, Mainz, Germany.;

    From the Departments of Neurosurgery (H.G.B.-S.) and Neuroradiology (K.R.), University Hospital, and the Institut of Neurosurgical Pathophysiology (L.K., A.H., O.K.), University of Mainz, Mainz, Germany.;

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