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首页> 外文期刊>American Journal of Neuroradiology >The Effect of Brain Tumors on BOLD Functional MR Imaging Activation in the Adjacent Motor Cortex: Implications for Image-guided Neurosurgery
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The Effect of Brain Tumors on BOLD Functional MR Imaging Activation in the Adjacent Motor Cortex: Implications for Image-guided Neurosurgery

机译：脑肿瘤对相邻运动皮层中大胆功能性MR成像激活的影响：对图像引导神经外科的影响。

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摘要

BACKGROUND AND PURPOSE: Functional MR (fMR) imaging data coregistered to a neurosurgical navigation system have been proposed as guides for the resection of brain tumor in or adjacent to eloquent cortices. The purpose of this study was to compare data obtained from the side of the brain affected by tumor with the contralateral side and to determine if there are physiological limitations of fMR imaging in accurately determining the location of the primary motor cortex. METHODS: Ten patients with tumors in or directly adjacent to the motor cortex were studied with fMR imaging (finger-tapping paradigm). fMR imaging data were analyzed using multiple R values. These data were coregistered to a real-time intraoperative neurosurgical navigation system. RESULTS: Significant variability of motor cortex activation patterns was noted among individual patients. The activation volumes on the side of the tumor were significantly smaller compared with the contralateral side for all tumors not previously resected (0.66±0.47). This was most pronounced in glioblastomas (0.27±0.21). We propose that these differences were caused by a loss of autoregulation in the tumor vasculature of glioblastomas and venous effects. CONCLUSION: Notwithstanding the differences noted, the motor cortex was identified successfully in all patients. This was confirmed by intraoperative physiological identification of the motor cortex and a lack of postoperative neurologic deficit.
机译：背景与目的：已建议在神经外科导航系统中共注册 的功能性MR（fMR）成像数据，作为在雄辩的或附近进行脑肿瘤切除的指南 。 皮质。这项研究的目的是比较 从受肿瘤影响的大脑一侧与对侧 一侧获得的数据，并确定是否存在生理限制 可以准确地确定 原发性运动皮层的位置。 方法：10例在 内或直接与之相邻的肿瘤患者用fMR成像（指轻敲 范例）研究皮层。使用多个R值分析了fMR成像数据。 将这些数据共同注册到实时术中神经外科手术 导航系统中。 结果：在个别患者中注意到运动皮层激活 模式。与先前未切除的所有肿瘤相比，肿瘤侧的激活 体积明显小于对侧（<6>±0.67）。这在胶质母细胞瘤 （0.27±0.21）中最为明显。我们认为这些差异是由胶质母细胞瘤肿瘤血管的自动调节功能丧失和静脉作用引起的。结论：尽管有这些差异，在所有患者中均成功识别了运动 皮质。 是通过 运动皮层的术中生理学鉴定和术后缺乏神经功能缺损来证实的。

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  • 来源
    《American Journal of Neuroradiology》 |2000年第8期|1415-1422|共8页
  • 作者

    Andrei I. Holodny; Michael Schulder; Wen-Ching Liu; Jonathan Wolko; Joseph A. Maldjian; Andrew J. Kalnin;

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    From the Departments of Radiology (A.I.H., W.C.L., A.J.K.) and Neurosurgery (M.S.), UMDNJ-New Jersey Medical School, Newark, NJ UMDNJ-New Jersey Medical School, Newark, NJ (J.W.) and the Department of Radiology (J.A.M.), University of Pennsylvania, Philadelphia, Pennsylvania.;

    From the Departments of Radiology (A.I.H., W.C.L., A.J.K.) and Neurosurgery (M.S.), UMDNJ-New Jersey Medical School, Newark, NJ UMDNJ-New Jersey Medical School, Newark, NJ (J.W.) and the Department of Radiology (J.A.M.), University of Pennsylvania, Philadelphia, Pennsylvania.;

    From the Departments of Radiology (A.I.H., W.C.L., A.J.K.) and Neurosurgery (M.S.), UMDNJ-New Jersey Medical School, Newark, NJ UMDNJ-New Jersey Medical School, Newark, NJ (J.W.) and the Department of Radiology (J.A.M.), University of Pennsylvania, Philadelphia, Pennsylvania.;

    From the Departments of Radiology (A.I.H., W.C.L., A.J.K.) and Neurosurgery (M.S.), UMDNJ-New Jersey Medical School, Newark, NJ UMDNJ-New Jersey Medical School, Newark, NJ (J.W.) and the Department of Radiology (J.A.M.), University of Pennsylvania, Philadelphia, Pennsylvania.;

    From the Departments of Radiology (A.I.H., W.C.L., A.J.K.) and Neurosurgery (M.S.), UMDNJ-New Jersey Medical School, Newark, NJ UMDNJ-New Jersey Medical School, Newark, NJ (J.W.) and the Department of Radiology (J.A.M.), University of Pennsylvania, Philadelphia, Pennsylvania.;

    From the Departments of Radiology (A.I.H., W.C.L., A.J.K.) and Neurosurgery (M.S.), UMDNJ-New Jersey Medical School, Newark, NJ UMDNJ-New Jersey Medical School, Newark, NJ (J.W.) and the Department of Radiology (J.A.M.), University of Pennsylvania, Philadelphia, Pennsylvania.;

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