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首页> 外文期刊>American Journal of Pathology >Vascular Repair After Menstruation Involves Regulation of Vascular Endothelial Growth Factor-Receptor Phosphorylation by sFLT-1
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Vascular Repair After Menstruation Involves Regulation of Vascular Endothelial Growth Factor-Receptor Phosphorylation by sFLT-1

机译：月经后的血管修复涉及sFLT-1对血管内皮生长因子受体磷酸化的调节

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摘要

Regeneration of the endometrium after menstruation requires a rapid and highly organized vascular response. Potential regulators of this process include members of the vascular endothelial growth factor (VEGF) family of proteins and their receptors. Although VEGF expression has been detected in the endometrium, the relationship between VEGF production, receptor activation, and endothelial cell proliferation during the endometrial cycle is poorly understood. To better ascertain the relevance of VEGF family members during postmenstrual repair, we have evaluated ligands, receptors, and activity by receptor phosphorylation in human endometrium throughout the menstrual cycle. We found that VEGF is significantly increased at the onset of menstruation, a result of the additive effects of hypoxia, transforming growth factor-, and interleukin-1ß. Both VEGF receptors, FLT-1 and KDR, followed a similar pattern. However, functional activity of KDR, as determined by phosphorylation studies, revealed activation in the late menstrual and early proliferative phases. The degree of KDR phosphorylation was inversely correlated with the presence of sFLT-1. Endothelial cell proliferation analysis in endometrium showed a peak during the late menstrual and early proliferative phases in concert with the presence of VEGF, VEGF receptor phosphorylation, and decrease of sFLT-1. Together, these results suggest that VEGF receptor activation and the subsequent modulation of sFLT-1 in the late menstrual phase likely contributes to the onset of angiogenesis and endothelial repair in the human endometrium.
机译：月经后子宫内膜的再生需要 迅速而高度有组织的血管反应。此过程的潜在调节物 包括蛋白质及其受体的血管内皮生长因子（VEGF）家族的成员。尽管在子宫内膜中检测到了VEGF 的表达，但子宫内膜周期中VEGF的产生，受体激活与内皮 细胞增殖之间的关系 为了更好地确定月经后修复过程中VEGF家族成员的相关性，我们评估了人类体内配体，受体， 和受体磷酸化的活性。在整个月经周期内子宫内膜 。我们发现，在月经开始时，VEGF显着升高，这是缺氧，转化生长因子和白介素-1ß的累加效应的结果。 < / sup>两种VEGF受体FLT-1和KDR都遵循相似的模式。 但是，通过磷酸化 研究确定的KDR的功能活性在晚期被激活。月经和早期 增生期。 KDR磷酸化程度 与sFLT-1的存在呈负相关。子宫内膜内皮 细胞增殖分析显示，在 一致的 的月经后期和早期增生阶段，存在一个峰值，存在VEGF，VEGF受体磷酸化，和 减少sFLT-1。总之，这些结果表明，VEGF 受体激活以及随后的sFLT-1 在月经后期的调节可能有助于血管生成 。和子宫内膜的内皮修复。

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  • 来源
    《American Journal of Pathology》 |2001年第4期|1399-1410|共12页
  • 作者

    Michael D. Graubert; Maria Asuncion Ortega; Bruce Kessel; Joseph F. Mortola; M. Luisa Iruela-Arispe;

  • 作者单位

    From the Department of Obstetrics and Gynecology,Division of Reproductive Endocrinology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts;

    and the Department of Molecular, Cell, and Developmental Biology and the Molecular Biology Institute,University of California–Los Angeles, Los Angeles, California;

    From the Department of Obstetrics and Gynecology,Division of Reproductive Endocrinology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts;

    From the Department of Obstetrics and Gynecology,Division of Reproductive Endocrinology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts;

    and the Department of Molecular, Cell, and Developmental Biology and the Molecular Biology Institute,University of California–Los Angeles, Los Angeles, California;

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