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首页> 外文期刊>The American Journal of Psychiatry >Very Low Birth Weight and Behavioral Symptoms of Attention Deficit Hyperactivity Disorder in Young Adulthood: The Helsinki Study of Very-Low-Birth-Weight Adults
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Very Low Birth Weight and Behavioral Symptoms of Attention Deficit Hyperactivity Disorder in Young Adulthood: The Helsinki Study of Very-Low-Birth-Weight Adults

机译:年轻人成年时极低的出生体重和注意缺陷多动障碍的行为症状:极低出生体重的成年人的赫尔辛基研究

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摘要

Children with very low birth weight (<1500 g) are at increased risk for attention deficit hyperactivity disorder (ADHD). Whether this increased risk continues into adulthood is unknown. The authors assessed behavioral symptoms of ADHD in a well-characterized cohort of very-low-birth-weight young adults who were either small for gestational age (less than two standard deviations below the Finnish mean) or appropriate for gestational age (within two standard deviations of the mean). A total of 162 very-low-birth-weight subjects (small for gestational age: N=52; appropriate for gestational age: N=110) and 172 term comparison subjects 18 to 27 years of age completed the Adult Problem Questionnaire, which yielded six exploratory factor analysis-derived subscales. Participants were also asked about substance use. Very-low-birth-weight adults in the small for gestational age subgroup scored higher on the executive dysfunctioning and emotional instability subscales of the Adult Problem Questionnaire than did those in the appropriate for gestational age subgroup and the comparison group. The appropriate for gestational age and comparison groups had similar scores on these subscales. On the alcohol use subscale of the Adult Problem Questionnaire, both the appropriate and small for gestational age subgroups scored lower than comparison subjects and also reported fewer risk-taking behaviors (alcohol, smoking, and use of recreational drugs) than did comparison subjects. Rather than very low birth weight per se, intrauterine growth retardation, as reflected by small for gestational age status in the very-low-birth-weight subjects, confers a risk for behavioral and emotional adversity related to ADHD in young adulthood.
机译:出生体重极低(<1500 g)的儿童患注意力缺陷多动障碍(ADHD)的风险增加。这种增加的风险是否持续到成年期尚不清楚。作者在一个特征明确的队列中,对极低出生体重的年轻人进行了多动症的行为评估,他们要么胎龄小(小于芬兰平均值两个标准差),要么适合胎龄(两个标准以内)均值偏差)。共有162名极低出生体重的受试者(胎龄小:N = 52;适合胎龄:N = 110)和172名18至27岁的足月比较受试者完成了《成人问题问卷》,六个探索性因素分析衍生的量表。与会者还被问到有关药物使用的问题。在成年问题调查表的执行功能障碍和情绪不稳子量表中,处于胎龄较小的小组的超低出生体重成年人的得分高于适于胎龄分组和比较组的那些。在这些子量表上,适合胎龄和对照组的得分相似。在成人问题问卷的酒精使用量表中,适合胎龄子组的人群和较小人群的得分均低于比较受试者,并且报告的冒险行为(饮酒,吸烟和使用休闲药)也少于比较受试者。子宫内发育迟缓本身并不是非常低的出生体重,而是由极低出生体重儿的胎龄状态所反映出的,这使青年人成年后发生ADHD相关的行为和情感逆境风险。

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    《The American Journal of Psychiatry》 |2008年第10期|p.1345-1353|共9页
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    Sonja Strang-Karlsson, M.D.Katri Räikkönen, Ph.D.Anu-Katriina Pesonen, Ph.D.Eero Kajantie, M.D., Ph.D.E. Juulia Paavonen, M.D., Ph.D.Jari Lahti, M.A.Petteri Hovi, M.D.Kati Heinonen, Ph.D.Anna-Ursa Järvenpää, M.D., Ph.D.Johan G. Eriksson, M.D., Ph.D.Sture Andersson, M.D., Ph.D.Presented in part at the annual meeting of the Pediatric Academic Societies, Toronto, May 4-8, 2007, and at the Fourth International Congress on Developmental Origins of Health and Disease, Utrecht, the Netherlands, Sept. 13-16, 2006. Received Jan. 17, 2008, revision received April 16, 2008, accepted April 30, 2008 (doi: 10.1176/ appi.ajp.2008.08010085). From the National Public Health Institute, Helsinki, the Hospital for Children and Adolescents, Helsinki University Central Hospital, the Departments of Psychology and Public Health, University of Helsinki, and the Finnish National Graduate School of Clinical Investigation, Helsinki. Address correspondence and reprint requests to Dr. Strang-Karlsson, Hospital for Children and Adolescents, Biomedicum 2, Tukholmankatu 8C, Helsinki University Central Hospital, PO Box 705, FI-00029 Helsinki, Finland, sonja.strang@helsinki.fi (e-mail).All authors report no competing interests.Supported by grants from the Academy of Finland, the Children's Castle Hospital Foundation, the Finnish Medical Society Duodecim, Finska Läkaresällskapet, the Finnish Foundation for Pediatric Research, the Finnish Special Governmental Subsidiary for Health Sciences, the Biomedicum Helsinki Foundation, the Jalmarr and Rauha Ahokas Foundation, the Juho Vainio Foundation, the Finnish National Graduate School of Clinical Investigation, the Novo Nordisk Foundation, the Päivikki and Sakari Sohlberg Foundation, the Signe and Ane Gyllenberg Foundation, the Yrjö Jahnsson Foundation, the Research Foundation of Orion Corporation, the Pediatric Graduate School at the University of Helsinki, the Perklén Foundation, the Wilhelm and Else Stockmann Foundation, and the University of Helsinki.The authors thank research nurses Paula Nyholm, Anne Kaski, Hilkka Puttonen, and Marita Suni, and for data management, Sigrid Rosten.,;

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