Estrogen in Men

Erik Wibowo; Richard Wassersug

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Estrogen in Men

机译：男性中的雌激素

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In 1889, French physician Charles Edouard Brown-Sequard injected himself with an experimental mixture of testicular blood, semen, and extract from dog and guinea pig testes. After just one day, the 72-year-old doctor claimed improvement in his forearm strength, mental ability, urinary stream, and strength of fecal expulsion. Once his account was published, numerous people sought rejuvenation with Brown-Sequard's "elixir of life." Soon various marketers offered similar concoctions. Many of the people who took these exotic infusions suffered inflammation and infection and received little or no therapeutic benefit. Nevertheless, the elixirs laid the groundwork for much of modern endocrinology, in particular for hormone therapies used to address a wide variety of disorders.

机译：1889年，法国医生查尔斯·爱德华·布朗·塞奎德（Charles Edouard Brown-Sequard）向其注射了睾丸血液，精液和狗和豚鼠睾丸提取物的实验混合物。仅仅一天后，这位72岁的医生声称他的前臂力量，精神能力，尿流和排便力量得到改善。他的叙述发表后，无数人开始追寻Brown-Sequard的“生命药剂”。不久，各种营销商都提供了类似的调料。服用这些异国注射液的许多人遭受炎症和感染，几乎没有或根本没有治疗益处。尽管如此，the剂为现代许多内分泌学奠定了基础，尤其是用于治疗多种疾病的激素疗法。

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来源
《American Scientist》 |2014年第6期|452-459|共8页
作者
Erik Wibowo; Richard Wassersug;
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作者单位

University of British Columbia and the Australian Research Centre in Sex,Health and Society at La Trobe University in Melbourne, Australia;

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收录信息美国《科学引文索引》(SCI);
原文格式 PDF
正文语种 eng
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1. Effects of estrogen on estrogen receptor expression in the bursal cells of chick embryos and steroidogenic enzymes gene expression in the bursa: relevance of estrogen receptor and estrogen synthesis in the bursa of chick embryos. [J] . Shin YoungHa, Shiraishi S., Narabara K., Animal Science Journal . 2012,第1a2期

机译：雌激素对雏鸡胚囊细胞中雌激素受体表达和法氏囊中类固醇生成酶基因表达的影响：雌激素受体与雏鸡胚囊中雌激素合成的相关性。
2. Placental expression of estrogen receptor beta and its hormone binding variant – comparison with estrogen receptor alpha and a role for estrogen receptors in asymmetric division and differentiation of estrogen-dependent cells [J] . Antonin Bukovsky, Michael R Caudle, Maria Cekanova, Reproductive Biology and Endocrinology . 2003,第1期

机译：胎盘中雌激素受体β及其激素结合变体的表达-与雌激素受体α的比较以及雌激素受体在雌激素依赖性细胞的不对称分裂和分化中的作用
3. Estrogen receptor transcription and transactivation: Estrogen receptor alpha and estrogen receptor beta - regulation by selective estrogen receptor modulators and importance in breast cancer [J] . Benita S Katzenellenbogen, John A Katzenellenbogen Breast Cancer Research . 2000,第5期

机译：雌激素受体的转录和反式激活：雌激素受体α和雌激素受体β-通过选择性雌激素受体调节剂的调控及其在乳腺癌中的重要性
4. BRAIN AROMATASE (CYP19A1B) IS A HIGHLY SENSITIVE GENE TO ESTROGENS AND XENO-ESTROGENS [C] . Francois Brion, Yann Le Page, Benjamin Piccini International Conference on Endocrine Disruptors . 2012

机译：脑芳族酶（CYP19A1B）是雌激素和Xeno - 雌激素的高度敏感基因
5. Overcoming Anti-Estrogen Resistance in Estrogen Receptor (ER)-Positive Breast Cancer: Rational Targeting of Phosphatidylinositol 3-Kinase (PI3K) and the Resurrection of Estrogen Therapy [D] . Hosford, Sarah 2018

机译：克服雌激素受体（ER）阳性乳腺癌中的抗雌激素抵抗：磷脂酰肌醇3-激酶（PI3K）的合理靶向和雌激素疗法的复活
6. Placental expression of estrogen receptor beta and its hormone binding variant – comparison with estrogen receptor alpha and a role for estrogen receptors in asymmetric division and differentiation of estrogen-dependent cells [O] . Antonin Bukovsky, Michael R Caudle, Maria Cekanova, 2003

机译：胎盘中雌激素受体β及其激素结合变体的表达-与雌激素受体α的比较以及雌激素受体在雌激素依赖性细胞的不对称分裂和分化中的作用
7. Placental expression of estrogen receptor beta and its hormone binding variant – comparison with estrogen receptor alpha and a role for estrogen receptors in asymmetric division and differentiation of estrogen-dependent cells [O] . 2003

机译：胎盘中雌激素受体β及其激素结合变体的表达-与雌激素受体α的比较以及雌激素受体在雌激素依赖性细胞的不对称分裂和分化中的作用
8. Bromine-80m-labeled estrogens: Auger-electron emitting, estrogen receptor-directed ligands with potential for therapy of estrogen receptor positive cancers [R] . 1988

机译：溴-80m标记的雌激素：俄歇电子发射，雌激素受体导向配体，具有治疗雌激素受体阳性癌症的潜力

Estrogen in Men

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