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首页> 外文期刊>Analytical and Bioanalytical Chemistry >Reduction of measurement uncertainty by experimental design in high-order (double, triple, and quadruple) isotope dilution mass spectrometry: application to GC-MS measurement of bromide
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Reduction of measurement uncertainty by experimental design in high-order (double, triple, and quadruple) isotope dilution mass spectrometry: application to GC-MS measurement of bromide

机译：通过实验设计降低高阶（双，三和四重）同位素稀释质谱法的测量不确定度：在溴化物的GC-MS测量中的应用

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摘要

Since its introduction a century ago, isotope dilution analysis has played a central role in developments of analytical chemistry. This method has witnessed many elaborations and developments over the years. To date, we have single, double, and even triple isotope dilution methods. In this manuscript, we summarize the conceptual aspects of isotope dilution methods and introduce the quadruple dilution and the concept of exact matching triple and quadruple dilutions. The comparison of isotope dilution methods is performed by determination of bromide ions in groundwater using novel ethyl-derivatization chemistry in conjunction with GC/MS. We show that the benefits of higher-order isotope dilution methods are countered with a greater need for careful experimental design of the isotopic blends. Just as for ID2MS, ID3MS and ID4MS perform best when the isotope ratio of one sample/spike blend is matched with that of a standard/spike blend (exact matching).
机译：自一个世纪前问世以来，同位素稀释分析在分析化学的发展中一直发挥着核心作用。多年来，这种方法经历了许多阐述和发展。迄今为止，我们有单，双甚至三重同位素稀释方法。在本手稿中，我们总结了同位素稀释方法的概念方面，并介绍了四倍稀释和精确匹配的三倍和四倍稀释的概念。同位素稀释方法的比较是通过使用新型乙基衍生化化学方法结合GC / MS测定地下水中的溴离子来进行的。我们表明，更高级别的同位素稀释方法的好处与对同位素混合物的仔细实验设计的更大需求相抵消。与ID2MS一样，当一种样品/长钉掺合物的同位素比与标准/长钉掺合物的同位素比匹配时（精确匹配），ID3MS和ID4MS的性能最佳。

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