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首页> 外文期刊>Andrologia >Ameliorative effects of stinging nettle (Urtica dioica) on testosterone-induced prostatic hyperplasia in rats
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Ameliorative effects of stinging nettle (Urtica dioica) on testosterone-induced prostatic hyperplasia in rats

机译：荨麻（Urtica dioica）对睾丸激素引起的大鼠前列腺增生的改善作用

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摘要

The present study investigated the effects of stinging nettle (Urtica dioica L.) (UD) on benign prostatic hyperplasia (BPH) induced by testosterone. In vitro studies were conducted to assess the 5-reductase inhibitory potential of UD. Two biochemical markers viz., β-sitosterol and scopoletin, were isolated and characterised in the extracts utilising High-performance thin layer chromatographic, FTIR, NMR and overlain UV spectral studies. Hyperplasia was induced in rats by subcutaneous administration of testosterone (3?mg?kg?1 s.c.) for 28?days in all the groups except the vehicle-treated group. Simultaneous administration of petroleum ether and ethanolic extracts (10, 20 and 50?mg?kg?1 p.o.) and isolated β-sitosterol (10 and 20?mg?kg?1 p.o.) was undertaken. Finasteride was used as a positive control (1?mg?kg?1 p.o.). Measurement of prostate/body weight ratio, weekly urine output and serum testosterone levels, prostate-specific antigen levels (on day 28) and histological examinations carried out on prostates from each group led us to conclude that UD can be used as an effective drug for the management of BPH.
机译：本研究调查了荨麻（Urtica dioica L.）（UD）对睾丸激素诱导的良性前列腺增生（BPH）的影响。进行了体外研究以评估UD的5-还原酶抑制潜力。利用高效薄层色谱，FTIR，NMR和覆盖紫外光谱研究分离出了两种生化标记物，即β-谷甾醇和大麦草皮素，并对其进行了表征。在除赋形剂治疗组以外的所有组中，通过皮下给予睾丸激素（3μg·kg·kg →1 s.c.）诱导大鼠增生28天。同时服用石油醚和乙醇提取物（10、20和50？mg？kg ？1 po）和分离的β-谷甾醇（10和20？mg？kg ？1 po）。非那雄胺被用作阳性对照（1？mg？kg ？1 p.o.）。测量前列腺/体重比，每周尿量和血清睾丸激素水平，前列腺特异性抗原水平（在第28天）以及对每组前列腺进行的组织学检查使我们得出结论，UD可以用作治疗以下疾病的有效药物BPH的管理。

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