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首页> 外文期刊>Animal Science Journal >Tissue distribution of albumin-glucose advanced glycation end products administrated to chickens
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Tissue distribution of albumin-glucose advanced glycation end products administrated to chickens

机译：鸡服用白蛋白-葡萄糖高级糖化终产物的组织分布

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摘要

Glycation (Maillard reaction) starts from non-enzymatic amino-carbonyl reaction binding carbonyl group of reducing sugars to amino group of amino acids. The amino-carbonyl reaction leads to the formation of the stable Amadori product, which ultimately forms advanced glycation end products (AGE). Acceleration of glycation during hyperglycemia increases the production and accumulation of AGE, which is implicated in the gradual development of diabetic complications in diabetes mellitus. Avian species offers the great advantage of providing animal models for diabetology because high blood glucose concentration should accelerate to generate high concentration of AGE. In the present study, radioactive AGE was prepared from chicken serum albumin and 14C-glucose. Radioactive AGE was administrated to examine the tissue distribution of AGE in chickens. Administration of radioactive AGE into the circulation of chickens revealed that AGE accumulated into specific tissues, liver, spleen and kidney, which have the function for clearing exogenous substances and endogenous metabolic waste products.
机译：糖基化（美拉德反应）始于将还原糖的羰基与氨基酸的氨基结合的非酶促氨基羰基反应。氨基羰基反应导致形成稳定的Amadori产物，最终形成高级糖基化终产物（AGE）。高血糖症期间糖化的加速增加了AGE的产生和积累，这与糖尿病中糖尿病并发症的逐步发展有关。禽类具有提供糖尿病动物模型的巨大优势，因为高血糖浓度会加速产生高浓度AGE。在本研究中，从鸡血清白蛋白和 14 C-葡萄糖制备了放射性AGE。放射性AGE被检查鸡中AGE的组织分布。将放射性AGE施用到鸡的血液中可以发现AGE积累在特定的组织，肝脏，脾脏和肾脏中，这些组织具有清除外源性物质和内源性代谢废物的功能。

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