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首页> 外文期刊>Annals of Biomedical Engineering >Flow-Induced Platelet Activation in Bileaflet and Monoleaflet Mechanical Heart Valves
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Flow-Induced Platelet Activation in Bileaflet and Monoleaflet Mechanical Heart Valves

机译：双叶和单叶机械心脏瓣膜中的血流诱导的血小板活化。

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摘要

A study was conducted to measure in vitro the procoagulant properties of platelets induced by flow through Carbomedics bileaflet and Bjork–Shiley monoleaflet mechanical heart valves (MHVs). Valves were mounted in a left ventricular assist device, and platelets were circulated through them under pulsatile flow. Platelet activation states (PAS) were measured during circulation using a modified prothrombinase method. Computational fluid dynamics (CFD) simulations of turbulent, transient, and non-Newtonian blood flow patterns generated by the two valve designs were done using the Wilcox k−ω turbulence model, and platelet shear-stress histories (the integral of shear-stress exposure with respect to time) through the two MHVs were calculated. PAS measurements indicated that the bileaflet MHV activated platelets at a rate more than twice that observed with the monoleaflet MHV. Turbulent flow patterns were evident in CFD simulations for both valves, and corroborated the PAS observations, showing that, for particles close to the leaflet(s), shear-stress exposure in the bileaflet MHV can be more than four times that in the monoleaflet valve.
机译：进行了一项研究，以测量体外流经Carbomedics双叶和Bjork-Shiley单叶机械心脏瓣膜（MHV）引起的血小板的促凝特性。瓣膜安装在左心室辅助装置中，血小板在脉动流下循环通过。使用改良的凝血酶原方法在循环过程中测量血小板活化状态（PAS）。使用Wilcoxk-ω湍流模型和血小板剪切应力历史记录（剪切应力暴露的积分），完成了由两种瓣膜设计产生的湍流，瞬态和非牛顿血流模式的计算流体力学（CFD）模拟。相对于时间）通过两个MHV进行了计算。 PAS测量表明，双叶MHV活化的血小板的速率是单叶MHV所观察到的速率的两倍以上。在两个阀门的CFD模拟中都可以看到湍流模式，并证实了PAS的观察结果，这表明，对于靠近小叶的颗粒，双叶MHV中的切应力暴露可能是单叶瓣中的四倍以上。 。

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