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首页> 外文期刊>Annals of Human Genetics >Wide Disparity in Genetic Admixture Among Mexican Americans from San Antonio, TX
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Wide Disparity in Genetic Admixture Among Mexican Americans from San Antonio, TX

机译：来自德克萨斯州圣安东尼奥市的墨西哥裔美国人之间遗传混合物的差异很大

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We studied 706 participants of the San Antonio Family Diabetes Study (SAFDS) and 586 male samples from the San Antonio Center for Biomarkers of Risk of Prostate Cancer (SABOR) and used 64 ancestry informative markers to compare admixture proportions between both groups. Existence of population substructure was demonstrated by the excess association of unlinked markers. In the SAFDS sample, ancestral proportions were estimated at 50.2 ± 0.6% European, 46.4 ± 0.6% Native American, and 3.1 ± 0.2% West African. For the SABOR sample, the proportions were 58.9 ± 0.7%, 38.2 ± 0.7%, and 2.9 ± 0.2%, respectively. Additionally, in the SAFDS subjects a highly significant negative correlation was found between individual Native American ancestry and skin reflectance (R2= 0.07, P= 0.00006). The correlation was stronger in males than in females but clearly showed that ancestry only accounts for a small percentage of the variation in skin color and, conversely, that skin reflectance is not a robust surrogate for genetic admixture. Furthermore, a substantial difference in substructure is present in the two cohorts of Mexican American subjects from the San Antonio area in Texas, which emphasizes that genetic admixture estimates should be accounted for in association studies, even for geographically related subjects.
机译：我们研究了圣安东尼奥家庭糖尿病研究（SAFDS）的706名参与者和圣安东尼奥前列腺癌风险生物标志物中心（SABOR）的586名男性样本，并使用64个祖先信息性标志物比较了两组之间的混合比例。未连接标记的过度关联证明了种群亚结构的存在。在SAFDS样本中，祖先所占比例估计为欧洲的50.2±0.6％，美洲印第安人的46.4±0.6％和西非的3.1±0.2％。对于SABOR样本，比例分别为58.9±0.7％，38.2±0.7％和2.9±0.2％。此外，在SAFDS受试者中，发现美国原住民血统与皮肤反射率之间存在极显着的负相关性（R 2 = 0.07，P = 0.00006）。男性之间的相关性强于女性，但清楚地表明，祖先只占肤色变化的一小部分，相反，皮肤反射率不是遗传混合物的有力替代品。此外，来自得克萨斯州圣安东尼奥地区的两个墨西哥裔美国人受试者的亚结构存在显着差异，这强调在关联研究中应考虑遗传混合物的估计，即使是与地理相关的受试者也应如此。

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