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首页> 外文期刊>Annals of the New York Academy of Sciences >Aging and cerebrovascular dysfunction: contribution of hypertension, cerebral amyloid angiopathy, and immunotherapy
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Aging and cerebrovascular dysfunction: contribution of hypertension, cerebral amyloid angiopathy, and immunotherapy

机译:衰老和脑血管功能障碍:高血压,脑淀粉样血管病和免疫疗法的贡献

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摘要

Age-related cerebrovascular dysfunction contributes to ischemic stroke, intracerebral hemorrhages (ICHs), microb-leeds, cerebral amyloid angiopathy (CAA), and cognitive decline. Importantly, there is increasing recognition that this dysfunction plays a critical secondary role in many neurodegenerative diseases, including Alzheimer's disease (AD). Atherosclerosis, hypertension, and CAA are the most common causes of blood-brain barrier (BBB) lesions. The accumulation of amyloid beta (Aβ) in the cerebrovascular system is a significant risk factor for ICH and has been linked to endothelial transport failure and blockage of perivascular drainage. Moreover, recent anti-Aβ immunotherapy clinical trials demonstrated efficient clearance of parenchymal amyloid deposits but have been plagued by CAA-associated adverse events. Although management of hypertension and atherosclerosis can reduce the incidence of ICH, there are currently no approved therapies for attenuating CAA. Thus, there is a critical need for new strategies that improve BBB function and limit the development of β-amyloidosis in the cerebral vasculature.
机译:与年龄有关的脑血管功能障碍导致缺血性中风,脑出血(ICH),微生物,脑淀粉样血管病(CAA)和认知能力下降。重要的是,人们越来越认识到这种功能障碍在包括阿尔茨海默氏病(AD)在内的许多神经退行性疾病中起着至关重要的辅助作用。动脉粥样硬化,高血压和CAA是血脑屏障(BBB)病变的最常见原因。脑血管系统中淀粉样β(Aβ)的积累是ICH的重要危险因素,并与内皮运输失败和血管周引流阻塞有关。此外,最近的抗Aβ免疫疗法临床试验表明,可以有效清除实质性淀粉样蛋白沉积物,但一直受到CAA相关不良事件的困扰。尽管高血压和动脉粥样硬化的治疗可以降低ICH的发生率,但目前尚无批准的减轻CAA的疗法。因此,迫切需要能够改善BBB功能并限制脑血管中β-淀粉样变性病发展的新策略。

著录项

  • 来源
    《Annals of the New York Academy of Sciences》 |2010年第207期|p.58-70|共13页
  • 作者单位

    Institute for Memory Impairments and Neurological Disorders, University of California, Irvine, Irvine, California;

    rnInstitute for Memory Impairments and Neurological Disorders, University of California, Irvine, Irvine, California;

    rnInstitute for Memory Impairments and Neurological Disorders, University of California, Irvine, Irvine, California;

    rnInstitute for Memory Impairments and Neurological Disorders, University of California, Irvine, Irvine, California Department of Neurology, University of California, Irvine, Irvine, California;

    rnDepartment of Pathology, University of California, Irvine, Irvine, California;

    rnDepartment of Neurology, University of California, Irvine, Irvine, California;

    rnDepartment of Neurology, Institute for Memory Impairments and Neurological Disorder, 1111 Gillespie NRF, University of California, Irvine, Irvine, CA 92697-4540;

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  • 原文格式 PDF
  • 正文语种 eng
  • 中图分类
  • 关键词

    alzheimer's disease; cerebral amyloid angiopathy; blood-brain barrier; immunotherapy; hypertension;

    机译:阿尔茨海默氏病;脑淀粉样血管病;血脑屏障;免疫疗法高血压;

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