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首页> 外文期刊>Annals of the New York Academy of Sciences >Acute anti-inflammatory approaches to ischemic stroke
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Acute anti-inflammatory approaches to ischemic stroke

机译：急性抗炎性方法治疗缺血性中风

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In preparation for designing and undertaking trials of strategies that can modulate "innate inflammation" to improve outcomes of ischemic injury, consideration of approaches that have managed cellular inflammation in ischemic stroke are instructive. Robust experimental work has demonstrated the efficacy (and apparent safety) of targeting PMN leukocyte-endothelial cell interactions in the early moments following focal ischemia onset in model systems. Four clinical trial programs were Undertaken to assess the safety and efficacy of inhibitors to PMN leukocyte interactions with the endothelial cell during ischemic stroke. Experiences in those clinical trial programs indicate specific limitations that halted progress in this line of investigation before an adequate hypothesis test could be achieved. Although innate inflammation is a central part of injury evolution following focal ischemia, great care in the translation from experimental studies to Phase I/II clinical safety assessments and to the design and conduct of Phase III trials is needed.
机译：在准备设计和进行可调节“先天性炎症”以改善缺血性损伤结果的策略的试验中，考虑在缺血性卒中中处理细胞炎症的方法具有指导意义。强大的实验工作证明了在模型系统中局部缺血发作后的早期，靶向PMN白细胞-内皮细胞相互作用的功效（和明显的安全性）。进行了四个临床试验计划，以评估缺血性中风期间PMN白细胞与内皮细胞相互作用抑制剂的安全性和有效性。这些临床试验计划的经验表明，在可以进行充分的假设检验之前，特定的限制因素阻止了该研究领域的进展。尽管先天性炎症是局灶性局部缺血后损伤发展的核心部分，但在从实验研究到I / II期临床安全性评估以及III期临床试验设计和进行的翻译中，需要格外小心。

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