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首页> 外文期刊>Annals of the New York Academy of Sciences >Reconsidering the 'protective' hypothesis of Helicobacter pylori infection in eosinophilic esophagitis
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Reconsidering the 'protective' hypothesis of Helicobacter pylori infection in eosinophilic esophagitis

机译：重新考虑嗜酸性食管炎幽门螺杆菌感染的“保护”假设

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Since its discovery,Helicobacter pylori(H. pylori) has attracted attention in the biomedical world with its numerous pathophysiologic implications, both gastrointestinal and systemic. Beyond its well-established carcinogenic properties, emerging evidence also supports "harmful" proinflammatory and neurodegenerative roles ofH. pylori. On the other hand,H. pyloriinfection has been proposed to be "protective" against several diseases, such as asthma and gastroesophageal reflux disease. Eosinophilic esophagitis (EoE) is a relatively new, allergen/immune-mediated disease, which has also been linked to these considerations. Main arguments are a postulated shift of immune responses byH. pylorifrom T helper 2 (T(H)2) to T(H)1 polarization, as well as a potential decline of theH. pyloriburden with the dramatic parallel rise of Epsilon omicron Epsilon: a series of observational studies reported an inverse association. In this review, we counter these arguments by providing further epidemiological data, which point out that this generalization might be rather incomplete. We also discuss the limitations of the existing studies evaluating a possible association. Furthermore, we provide current evidence on common pathogenetic components, which share both entities. In summary, the claim thatH. pyloriis protective against EoE is rather incomplete, and further mechanistic studies are necessary to elucidate a possible association.
机译：自发现以来，幽门螺杆菌（H.Pylori）引起了生物医学世界的注意力，其胃肠和系统性均有众多病理生理学意义。超出其良好的致癌性能，新兴的证据也支持“有害”的促炎和神经变性作用。幽门螺杆菌。另一方面，h。已经提出幽门螺酰脲对几种疾病（例如哮喘和胃食管反）“保护性”。嗜酸性食道炎（EOE）是一种相对较新的过敏原/免疫介导的疾病，其也与这些考虑相连。主要论证是免疫反应的假期转变。 Pylorifrom T辅助辅助2（t（h）2）至t（h）1极化，以及潜在的潜在下降。幽门螺杆上的epsilonomicron epsilon的戏剧性平行升起：一系列观察研究报告了一系列反向关联。在这篇综述中，我们通过提供进一步的流行病学数据来抵消这些论点，这指出这种概括可能是不完整的。我们还讨论了现有研究评估可能协会的局限性。此外，我们提供关于常见致病成分的现有证据，该组分分享两个实体。总之，索赔当然幽门螺杆菌保护对抗EOE是相当不完整的，并且需要进一步的机械研究来阐明可能的关联。

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