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首页> 外文期刊>Annals of the New York Academy of Sciences >Recent insights into the biology of Barrett's esophagus
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Recent insights into the biology of Barrett's esophagus

机译:最近洞察巴雷特食道生物学

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摘要

Barrett's esophagus (BE) is the only known precursor to esophageal adenocarcinoma (EAC), an aggressive cancer with a poor prognosis. Our understanding of the pathogenesis and Barrett's metaplasia is incomplete, and this has limited the development of new therapeutic targets and agents, risk stratification ability, and management strategies. This review outlines current insights into the biology of BE and addresses controversies surrounding cell of origin, cellular reprogramming theories, updates on esophageal epithelial barrier function, and the significance of goblet cell metaplasia and its association with malignant change. Further research into the basic biology of BE is vital as it will underpin novel therapies and improve our ability to predict malignant progression and help identify the minority of patients who will develop EAC.
机译:巴雷特的食道(BE)是食管腺癌(EAC)的唯一已知的前体,具有较差的侵略性癌症。我们对发病机制和Barrett的荟萃的理解是不完整的,这有限于开发新的治疗目标和代理,风险分层能力和管理策略。本综述概述了目前对生物,细胞重编程理论,食管上皮屏障函数的围绕细胞周围的争议的生物学的洞察力,以及对恶性变化的转脚细胞传媒的重要性。进一步研究对Be的基本生物学是至关重要的,因为它将基于新的疗法,提高我们预测恶性进展的能力,并帮助确定将开发EAC的少数患者。

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