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首页> 外文期刊>Annals of the New York Academy of Sciences >Designer drugs: a medicinal chemistry perspective (Ⅱ)
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Designer drugs: a medicinal chemistry perspective (Ⅱ)

机译:设计师药物:药用化学观点(Ⅱ)

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摘要

During 2012-2018, the clandestine manufacture of new psychoactive substances (NPS) designed to circumvent substance control regulations increased exponentially worldwide, with concomitant increase in fatalities. This review focuses on three compound classes identified as synthetic opioids, synthetic amphetamines, and synthetic cannabinoids and highlights the medicinal chemistry precedents utilized by clandestine laboratories to develop new NPS with increased brain penetration, longer duration of action, and greater potency. Chemical approaches to illicit drug abuse treatment options, particularly for opioid use disorder, are also discussed.
机译:在2012 - 2018年期间,旨在规避物质控制法规的新精神活性物质(NPS)的秘密制造在全球范围内呈指数增长,伴随着死亡的增加。本综述重点关注鉴定为合成阿片类药物,合成疗法和合成大麻素的三种复合类,并突出了秘密实验室使用的药物化学原因,以开发新的NPS,随着脑渗透,持续时间较长,行动持续时间和更大的效力。还讨论了非法药物滥用治疗方案的化学方法,特别是对于阿片类药物使用障碍。

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