Statistical methods in genetics: From microarrays to genetic epidemiology - an overview

Iris Pigeot; Karin Bammann; Achim Reineke; Nina Wawro; Astrid Zierer

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Statistical methods in genetics: From microarrays to genetic epidemiology - an overview

机译：遗传学中的统计方法：从微阵列到遗传流行病学-概述

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With the complete sequencing of the human genome in 2003 an immense step towards the biological understanding of human beings has been taken. This paper describes how the information at hand now can be used in the field of genetic epidemiology to analyze the role of genes in the etiology of diseases. We give a short introduction to genetics and review preprocessing and analytical techniques for microarray data before we cover traditional study designs. Finally we present in detail family and population based methods that enable to locate and identify candidate genes involved in the development of diseases. The outlook provides the reader with selected untackled problems and research areas.

机译：随着2003年人类基因组测序的完成，迈出了迈向人类生物学理解的巨大一步。本文介绍了当前的信息如何在遗传流行病学领域中用于分析基因在疾病病因中的作用。在介绍传统研究设计之前，我们将简要介绍遗传学，并回顾微阵列数据的预处理和分析技术。最后，我们详细介绍了基于家庭和人群的方法，这些方法能够定位和识别参与疾病发展的候选基因。前景为读者提供了一些未解决的问题和研究领域。

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来源
《Jahresbericht der Deutschen Mathematiker-Vereinigung》 |2004年第1期|p.3-38|共36页
作者
Iris Pigeot; Karin Bammann; Achim Reineke; Nina Wawro; Astrid Zierer;
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作者单位

Bremen Institute for Prevention Research and Social Medicine, Institute of Statistics, University of Bremen;

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原文格式 PDF
正文语种 eng
中图分类数学;
关键词
association; genetic epidemiology; linkage; microarrays;

机译：关联;遗传流行病学;连锁;微阵列;

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1. Statistical superiority of genome-probing microarrays as genomic DNA-DNA hybridization in revealing the bacterial phylogenetic relationship compared to conventional methods [J] . Chang HW, Nam YD, Jung MY, Journal of Microbiological Methods . 2008,第3期

机译：与传统方法相比，基因组探测微阵列作为基因组DNA-DNA杂交在揭示细菌系统发生关系方面的统计优势
2. Commentary: Connections between genetics and statistics: a commentary on Fisher's 1951 Bateson lecture--'Statistical Methods in Genetics'. [J] . Bodmer WF International Journal of Epidemiology: Official Journal of the International Epidemiological Association . 2010,第2期

机译：评论：遗传学与统计学之间的联系：关于费舍尔1951年Bateson演讲“遗传学中的统计方法”的评论。
3. Commentary: Connections between genetics and statistics: a commentary on Fisher’s 1951 Bateson lecture—‘Statistical Methods in Genetics’ [J] . li class=last id=contrib-1 class=nameclass=name-search href=/search?author1=Walter+F+Bodmersortspec=datesubmit=SubmitWalter F Bodmer/a International Journal of Epidemiology . 2010,第2期

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4. MELANOCYTIC TUMORS - EPIDEMIOLOGY, GENETICS AND TREATMENTMETHODS [C] . American College of Veterinary SurgeonsACVS Surgery Summit . 2015

机译：黑素细胞肿瘤 - 流行病学，遗传学和治疗方法
5. Statistical methods for the analysis of genetic marker and microarray data. [D] . Yu, Xiang. 2004

机译：分析遗传标记和微阵列数据的统计方法。
6. Statistical and Computational Methods for Genetic Diseases: An Overview [O] . Francesco Camastra, Maria Donata Di Taranto, Antonino Staiano 2015

机译：遗传疾病的统计和计算方法：概述
7. Commentary: Connections between genetics and statistics: a commentary on Fisher's 1951 Bateson lecture--'Statistical Methods in Genetics' [O] . W. F. Bodmer 2010

机译：评论：遗传学与统计数据之间的联系：对Fisher 1951 Bateson讲座的评论 - “遗传学统计方法”

Statistical methods in genetics: From microarrays to genetic epidemiology - an overview

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