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Characterisation of northern Patagonian bentonites for pharmaceutical uses

机译：北部巴塔哥尼亚膨润土的药用特征

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摘要

This paper evaluates the suitability of some smectite-rich samples from northern Patagonia (Argentina) for pharmaceutical use. The clays must comply with some general features before considering their use in pharmacy, including high mineral and chemical purity and the absence of microbial pathogens. Specific characteristics such as sediment volume, swelling power and gel formation are also important for particular applications such as their use as suspending agent. The mineralogical and chemical compositions of the samples are typical of bentonites, mainly consisting of montmorillonite. Considering the requisites of major pharmacopoeias for the use of silicates in pharmacy and taking into account the microbiological results, we could designate a pharmaceutically acceptable denomination for all samples, although some of them might need removal of quartz. The chemical, textural and porosimetric properties showed some differences between the samples that would affect their particular technical properties as pharmaceutical excipients. The samples could be used in pharmacy for topical applications as suspending agent. Regarding their use as adsorbents, specific sorption studies could help to discriminate their usefulness, as suggested by their high CEC values.
机译：本文评估了一些来自巴塔哥尼亚北部（阿根廷）的富含绿土的样品在制药上的适用性。在考虑将其用于制药行业之前，这些粘土必须符合一些一般特征，包括高矿物质和化学纯度以及不存在微生物病原体。诸如沉积物体积，溶胀力和凝胶形成之类的特定特性对于特定应用（例如用作悬浮剂）也很重要。样品的矿物学和化学组成是典型的膨润土，主要由蒙脱石组成。考虑到在药房中使用硅酸盐的主要药典的必要性，并考虑到微生物学结果，我们可以为所有样品指定药学上可接受的名称，尽管其中一些样品可能需要去除石英。化学，质地和孔隙率性质表明样品之间存在一些差异，这会影响它们作为药物赋形剂的特殊技术性能。样品可以在药房中作为悬浮剂用于局部应用。关于它们作为吸附剂的用途，如其高CEC值所暗示的，特定的吸附研究可以帮助区分它们的有用性。

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