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External perturbation manifested system size resonance in a mesoscopic hormone signaling model

机译：外部扰动在介观激素信号传导模型中表现出系统大小共振

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摘要

In mesoscopic reaction systems that contain only finite number of reactants, molecular fluctuation (or the so called internal noise), which can be characterized by the system size, plays an important role in nonlinear systems. In this work, the effect of internal noise is studied in a mesoscopic hormone signaling model with the presence of external perturbations (noise or signal). Simulation results reveal that the internal noise can play a constructive role to optimize the regularity of the noise induced internal signal only when external perturbation is present. This is a novel external perturbations induced system size resonance, which indicates that in complex mesoscopic systems, the system can automatically avoid the destructive environmental effects by tuning its size. Such kind of nontrivial cooperative effect may attribute to the fact that external perturbations broadened the regulation scope of the key mutual feedback. Therefore, current finding is of practical significance for similar physiological systems where the intercellular regulation plays the dominate role for signaling.
机译：在仅包含有限数量反应物的介观反应系统中，可以通过系统大小来表征的分子波动（或所谓的内部噪声）在非线性系统中起着重要的作用。在这项工作中，在存在外部扰动（噪声或信号）的介观激素信号传导模型中研究了内部噪声的影响。仿真结果表明，只有当存在外部扰动时，内部噪声才可以发挥建设性的作用，以优化噪声引起的内部信号的规则性。这是一种新颖的外部扰动引起的系统尺寸共振，这表明在复杂的介观系统中，系统可以通过调整其尺寸来自动避免破坏性的环境影响。这种非平凡的合作效应可能归因于以下事实：外部干扰扩大了关键相互反馈的调节范围。因此，当前的发现对于类似的生理系统具有实际意义，在类似的生理系统中，细胞间调节在信号传导中起主要作用。

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  • 来源
    《Applied Mathematical Modelling》 |2012年第12期|p.6236-6242|共7页
  • 作者

    Lin Ji; Xuan Yang; Bin Liu; Weiguo Xu;

  • 作者单位

    Department of Chemistry, Capital Normal University, Beijing 100048, China,Department of Statistic, Rice University, Houston, TX 77005, USA;

    Department of Statistic, Rice University, Houston, TX 77005, USA;

    Department of Chemistry, Capital Normal University, Beijing 100048, China;

    Department of Publication/NSFC, 83 Shuangqing Road Haidian District, Beijing 100085, China;

  • 收录信息 美国《科学引文索引》(SCI);美国《工程索引》(EI);
  • 原文格式 PDF
  • 正文语种 eng
  • 中图分类
  • 关键词

    system size resonance; mesoscopic system; internal noise; cooperative effect;

    机译：系统尺寸共振;介观系统内部噪音合作效应;

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