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A repeated-dose model of percutaneous drug absorption

机译:经皮药物吸收的重复剂量模型

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摘要

A mathematical model is developed for percutaneous absorption with regular applications of the drug. The linear partial differential equations (PDEs) of the model are solved using a finite-difference method which is second-order accurate in space and time. The solutions of these PDEs give the concentrations of the drug in the vehicle and the skin at a given time. The numerical results obtained are adapted to monitor the amount of drug released form the vehicle, the bio-availability for each application, the amount of drug in the skin at a given time, and the flux form the skin to the capillary at a given time.
机译:建立了数学模型,用于定期应用药物进行经皮吸收。使用有限差分方法求解模型的线性偏微分方程(PDE),该方法在空间和时间上都是二阶精度的。这些PDE的溶液在给定的时间给出了媒介物和皮肤中药物的浓度。获得的数值结果适用于监控从载体释放的药物量,每种应用的生物利用度,给定时间皮肤中的药物量以及给定时间从皮肤到毛细管的通量。

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