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首页> 外文期刊>Applied Mathematical Modelling >Theoretical study of diffusional release of a dispersed solute from cylindrical polymeric matrix: A novel configuration for providing zero-order release profile
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Theoretical study of diffusional release of a dispersed solute from cylindrical polymeric matrix: A novel configuration for providing zero-order release profile

机译：从圆柱形聚合物基质分散溶液的扩散释放的理论研究：一种用于提供零阶释放曲线的新型构造

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摘要

In the context of controlled release drug delivery approaches, the systems providing zero-order release kinetics have special advantages. Through employing these systems, drug concentration could be maintained within the therapeutic window over release time; thus maximum effectiveness alongside minimized side effects of the drug are achieved. However, obtaining zero-order drug release is extremely challenging. One of the main obstacles is the fact that implemented devices should be designed to overcome the decreasing mass transfer driving force, especially, in polymeric systems in which diffusion mechanism is dominant. In this study, we developed a new configuration of a polymeric matrix containing dispersed solute which provides sustained zero-order release. A combination of two innovative approaches including separating baffles and a two-layer coating was proposed to be incorporated into the conventional cylindrical polymeric matrix to induce zero-order release behavior. Then, an approximate mathematical model was developed to investigate the performance of the system under different conditions. The simulated results showed the potential of proposed configuration to be used as a carrier for sustained zero-order release. (C) 2019 Elsevier Inc. All rights reserved.
机译：在受控释放药物递送方法的背景下，提供零阶释放动力学的系统具有特殊的优点。通过采用这些系统，可以在治疗窗口中保持药物浓度超过释放时间;因此，实现了药物的最大效果。然而，获得零级药物释放非常具有挑战性。主要障碍之一是所实施的装置应该设计成克服降低的传质驱动力，尤其是在扩散机构优势的聚合物系统中。在该研究中，我们开发了一种含有分散溶质的聚合物基质的新构型，其提供持续的零阶释放。提出了两种创新方法的组合，包括分离挡板和双层涂层，以掺入常规的圆柱形聚合物基质中以诱导零阶释放行为。然后，开发了近似数学模型来研究系统在不同条件下的性能。模拟结果表明，用于持续零阶释放的载波的所提出的配置的潜力。 （c）2019 Elsevier Inc.保留所有权利。

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