...
  • 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Applied Mathematical Modelling >Dynamics of p53 regulatory network in DNA damage response
【24h】

Dynamics of p53 regulatory network in DNA damage response

机译：DNA损伤反应P53监管网络的动态

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

The tumor suppressor p53 plays a central role in the DNA damage response by inducing cell cycle arrest or apoptosis and several recent experiments have shown interesting dynamics in p53 protein expression during the repair cycle. In this paper, based on the three-module model proposed by Chickermane et al., a general model of delayed p53 regulatory network in the DNA damage response is formulated by introducing ubiquitous transcription and translation delays in the p53-Mdm2 oscillator module proposed by Zhang et al.. The dynamics of p53 regulatory network in DNA damage response are investigated through analytic analysis and numerical methods. It turns out that the pulsatile behavior can be generated due to initial DNA damage signals and ATM shows a switch-like behavior and relays the DNA damage signal. Moreover, the delays required for transcription and translation in Mdm2 gene expression can drive p53 to be oscillatory and an optimal rate of model parameters is also essential to these oscillations. Furthermore, the length of these delays can determine the amplitude and period of the oscillations. These results may provide a perspective for the development of anti-cancer therapy.
机译：肿瘤抑制器P53在DNA损伤响应中发挥着中心作用，通过诱导细胞周期骤停或细胞凋亡，并且在修复周期期间，最近的几个实验显示了P53蛋白表达中的有趣动态。本文基于Chickermane等人提出的三模模型。，通过引入Zhang提出的P53-MDM2振荡器模块中的无处不在的转录和翻译延迟，制定了DNA损伤响应中延迟P53调节网络的一般模型。通过分析分析和数值方法研究了DNA损伤反应中P53调节网络的动态。事实证明，由于初始DNA损伤信号，ATM可以产生脉冲性行为，并且ATM显示交换机的行为并继承DNA损伤信号。此外，MDM2基因表达中转录和翻译所需的延迟可以驱动P53是振荡的，并且模型参数的最佳速率对这些振荡也是必不可少的。此外，这些延迟的长度可以确定振荡的幅度和周期。这些结果可以为抗癌治疗的发展提供视角。

著录项

  • 来源
    《Applied Mathematical Modelling》 |2020年第12期|701-714|共14页
  • 作者

    Chunyan Gao; Fangqi Chen;

  • 作者单位

    Department of Mechanics Nanjing University of Aeronautics and Astronautics Nanjing 210016 PR China;

    Department of Mathematics Nanjing University of Aeronautics and Astronautics Nanjing 210016 PR China College of Mathematics and Systems Science Shandong University of Science and Technology Qingdao 266590 PR China;

  • 收录信息 美国《科学引文索引》(SCI);美国《工程索引》(EI);
  • 原文格式 PDF
  • 正文语种 eng
  • 中图分类
  • 关键词

    p53 oscillation; Delay; System parameters; Dynamics;

    机译：P53振荡;延迟;系统参数;动力学;

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号