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Modelling the spread of schistosomiasis in humans with environmental transmission

机译:用环境传动模拟人类血吸虫病的传播

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Although schistosomiasis containment campaigns have recorded substantial success in most developed countries, sub-Saharan Africa still suffers greatly under the burden of the disease. A basic mathematical model to assess the impact of concomitant immunity in humans and environmental transmission of schistosomiasis disease progression is formulated. Mathematical analysis is carried out to establish the existence of the equilibrium points providing necessary conditions for their local and global stability. Numerical simulations are done to analyze the effects of environmental transmission and processes associated with development of concomitant immunity. Our results suggest that schistosomiasis burden is increased by direct and indirect contribution of individuals with concomitant immunity to the schistosomiasis infection chain, increasing the shedding of miracidia upto the development of cercariae promoting the growth of cercariae, increase in environmental transmission due to cercariae, reducing the clearance rate of cercariae and reducing the development of humans and non-human mammals escape mechanisms from cercariae attack.
机译:虽然血吸虫病遏制运动在大多数发达国家录得巨大成功,但撒哈拉以南非洲仍然受到疾病的负担。制定了评估人类伴随免疫力和环境传播的基本数学模型,以及血吸虫病进展的影响。进行数学分析,以确定为局部和全球稳定性提供必要条件的均衡点的存在。完成数值模拟以分析环境传播和与伴随豁免发展相关的过程的影响。我们的研究结果表明,血吸虫病负担因伴随血吸虫病感染链的伴随抗扰度的直接和间接贡献而增加​​,增加了Miracidia的脱落,促进了Cercariae的生长,增加了因森卡里亚因环境传播而增加的,减少了Cercariae的清关率,减少人类和非人类哺乳动物的发展从Cercariae攻击中的逃避机制。

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