Metabolic engineering towards biotechnological production of carotenoids in microorganisms

P. Lee; C. Schmidt-Dannert

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Metabolic engineering towards biotechnological production of carotenoids in microorganisms

机译：微生物工程中类胡萝卜素生物技术生产的代谢工程

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Carotenoids are important natural pigments produced by many microorganisms and plants. Traditionally, carotenoids have been used in the feed, food and nutraceutical industries. The recent discoveries of health-related beneficial properties attributed to carotenoids have spurred great interest in the production of structurally diverse carotenoids for pharmaceutical applications. The availability of a considerable number of microbial and plant carotenoid genes that can be functionally expressed in heterologous hosts has opened ways for the production of diverse carotenoid compounds in heterologous systems. In this review, we will describe the recent progress made in metabolic engineering of non-carotenogenic microorganisms for improved carotenoid productivity. In addition, we will discuss the application of combinatorial and evolutionary strategies to carotenoid pathway engineering to broaden the diversity of carotenoid structures synthesized in recombinant hosts.

机译：类胡萝卜素是许多微生物和植物产生的重要天然色素。传统上，类胡萝卜素已用于饲料，食品和营养保健行业。归因于类胡萝卜素的与健康相关的有益特性的最新发现激发了人们对生产用于药物应用的结构多样的类胡萝卜素的兴趣。可以在异源宿主中功能表达的大量微生物和植物类胡萝卜素基因的可用性为在异源系统中生产各种类胡萝卜素化合物开辟了道路。在这篇综述中，我们将描述非类胡萝卜素微生物的代谢工程在提高类胡萝卜素生产率方面的最新进展。此外，我们将讨论组合和进化策略在类胡萝卜素途径工程中的应用，以扩大重组宿主中合成的类胡萝卜素结构的多样性。

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《Applied Microbiology and Biotechnology》 |2002年第2期|1-11|共11页
作者
P. Lee; C. Schmidt-Dannert;
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Department of Biochemistry Molecular Biology and Biophysics University of Minnesota 1479 Gortner Avenue St. Paul MN 55108 USA;

Department of Biochemistry Molecular Biology and Biophysics University of Minnesota 1479 Gortner Avenue St. Paul MN 55108 USA;

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1. Metabolic engineering towards biotechnological production of carotenoids in microorganisms [Review] [J] . Lee PC., Schmidt-Dannert C. Applied Microbiology and Biotechnology . 2002,第1a2期

机译：微生物工程中类胡萝卜素生物技术生产的代谢工程[综述]
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Metabolic engineering towards biotechnological production of carotenoids in microorganisms

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