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Factors influencing the internalization of Staphylococcus aureus and impacts on the course of infections in humans

机译：影响金黄色葡萄球菌内在化的因素及其对人类感染过程的影响

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摘要

Staphylococcus aureus is the primary etiological agent of several human diseases. S. aureus has classically been considered an extracellular pathogen; however, recent evidence indicates that S. aureus invades and persists in non-professional phagocytes. Experiments demonstrate that actin microfilaments, microtubules, receptor-mediated endocytosis, and protein tyrosine kinases play important roles in the uptake of S. aureus. Fibronectin-binding proteins and β1-integrins are implicated as critical cell surface molecules associated with internalization of S. aureus by non-phagocytic cells. Following invasion of eukaryotic cells, S. aureus induces the release of cytokines that have the potential to exacerbate disease and induce apoptosis. Finally, S. aureus has the ability to persist inside host cells as small colony variants, a phenotype associated with persistent and recurrent infections.
机译：金黄色葡萄球菌是几种人类疾病的主要病因。金黄色葡萄球菌通常被认为是一种细胞外病原体。然而，最近的证据表明，金黄色葡萄球菌侵入并持续存在于非专业吞噬细胞中。实验表明，肌动蛋白微丝，微管，受体介导的内吞作用和蛋白酪氨酸激酶在金黄色葡萄球菌的摄取中起重要作用。纤连蛋白结合蛋白和β1-整合素被认为是与非吞噬细胞内在的金黄色葡萄球菌内在化有关的关键细胞表面分子。侵染真核细胞后，金黄色葡萄球菌会诱导释放出可能加剧疾病并诱导凋亡的细胞因子。最后，金黄色葡萄球菌具有以小菌落变体形式存在于宿主细胞内的能力，这种表型与持续性和复发性感染有关。

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    《Applied Microbiology and Biotechnology》 |2001年第4期|361-366|共6页
  • 作者

    E. Alexander; M. Hudson;

  • 作者单位

    Department of Biology University of North Carolina at Charlotte 9201 University City Boulevard Charlotte NC 28223 USA;

    Department of Biology University of North Carolina at Charlotte 9201 University City Boulevard Charlotte NC 28223 USA;

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