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Anti-infection activity of nanostructured titanium percutaneous implants with a postoperative infection model

机译：纳米结构钛皮植入物术后感染模型的抗感染活性

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摘要

The titanium percutaneous implants were widely used in clinic; however, they have an increased risk of infection since they breach the skin barrier. Lack of complete skin integration with the implants can cause infection and implant removal. In this work, three titania nanotubes (TNT) with different diameters, 50 nm (TNT-50), 100 nm (TNT-100) and 150 nm (TNT-150) arrays were prepared on titanium surfaces by anodization, pure titanium (pTi) was used as control. Samples were characterized by scanning electron microscopy (SEM), atomic force microscopy (AFM), and contact angle analysis. The antibacterial efficiency of TNT was evaluated in vitro against Staphylococcus aureus under the visible light. The results indicated that TNT-100 had the highest antibacterial efficiency under the visible light. Subsequently, TNT implants and pTi implants were placed subcutaneously to the dorsum of New Zealand White rabbits, 10(8) CFU S. aureus was inoculated into the implant sites 4 h after surgery. The TNF-alpha and IL-1alpha were determined using enzyme linked immunoassay (ELISA). TNT implants revealed less inflammatory factor release than pTi implants with or without injected S. aureus liquid. According to the histological results, the TNT implants displayed excellent tissue integration. Whereas, pTi implants were surrounded with fibrotic capsule, and the skin tissue was almost separated from the implant surface. Therefore, the TNT significantly inhibited the infection risk and enhanced tissue integration of the percutaneous implants compared to pTi. The immersion test in the culture medium suggested that one of causes be probably more proteins adsorbed on TNT than on pTi. (C) 2015 Elsevier B.V. All rights reserved.
机译：钛经皮植入物在临床上得到了广泛的应用。但是，由于它们破坏了皮肤屏障，因此感染的风险增加。皮肤无法与植入物完全融合会导致感染和植入物移出。在这项工作中，通过阳极氧化在钛表面制备了三个直径分别为50 nm（TNT-50），100 nm（TNT-100）和150 nm（TNT-150）的二氧化钛纳米管（TNT），即纯钛（pTi ）用作对照。通过扫描电子显微镜（SEM），原子力显微镜（AFM）和接触角分析对样品进行表征。在可见光下，体外评价了TNT对金黄色葡萄球菌的抗菌效果。结果表明，TNT-100在可见光下具有最高的抗菌效率。随后，将TNT植入物和pTi植入物皮下放置在新西兰白兔的背部皮下，在手术后4小时将10（8）CFU金黄色葡萄球菌接种到植入物部位。使用酶联免疫法（ELISA）测定TNF-α和IL-1alpha。与注射或不注射金黄色葡萄球菌液体的pTi植入物相比，TNT植入物显示出较少的炎性因子释放。根据组织学结果，TNT植入物表现出出色的组织整合性。而pTi植入物被纤维化囊包裹，皮肤组织几乎与植入物表面分离。因此，与pTi相比，TNT显着抑制了感染风险并增强了经皮植入物的组织整合。在培养基中的浸没测试表明，原因之一可能是TNT上吸附的蛋白质比pTi上吸附的蛋白质更多。 （C）2015 Elsevier B.V.保留所有权利。

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  • 来源
    《Applied Surface Science》 |2015年第30期|119-127|共9页
  • 作者

    Tan Jing; Li Yiting; Liu Zhiyuan; Qu Shuxin; Lu Xiong; Wang Jianxin; Duan Ke; Weng Jie; Feng Bo;

  • 作者单位

    Southwest Jiaotong Univ, Sch Mat Sci & Engn, Minist Educ, Key Lab Adv Technol Mat, Chengdu, Sichuan, Peoples R China;

    Southwest Jiaotong Univ, Sch Mat Sci & Engn, Minist Educ, Key Lab Adv Technol Mat, Chengdu, Sichuan, Peoples R China;

    Southwest Jiaotong Univ, Sch Mat Sci & Engn, Minist Educ, Key Lab Adv Technol Mat, Chengdu, Sichuan, Peoples R China;

    Southwest Jiaotong Univ, Sch Mat Sci & Engn, Minist Educ, Key Lab Adv Technol Mat, Chengdu, Sichuan, Peoples R China;

    Southwest Jiaotong Univ, Sch Mat Sci & Engn, Minist Educ, Key Lab Adv Technol Mat, Chengdu, Sichuan, Peoples R China;

    Southwest Jiaotong Univ, Sch Mat Sci & Engn, Minist Educ, Key Lab Adv Technol Mat, Chengdu, Sichuan, Peoples R China;

    Southwest Jiaotong Univ, Sch Mat Sci & Engn, Minist Educ, Key Lab Adv Technol Mat, Chengdu, Sichuan, Peoples R China;

    Southwest Jiaotong Univ, Sch Mat Sci & Engn, Minist Educ, Key Lab Adv Technol Mat, Chengdu, Sichuan, Peoples R China;

    Southwest Jiaotong Univ, Sch Mat Sci & Engn, Minist Educ, Key Lab Adv Technol Mat, Chengdu, Sichuan, Peoples R China;

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  • 正文语种 eng
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  • 关键词

    Titania nanotubes; Antibacterial efficiency; Percutaneous implantation; Anti infection property;

    机译：二氧化钛纳米管;抗菌效率;经皮植入;抗感染性能;

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