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首页> 外文期刊>Applied Surface Science >Chitin butyrate coated electrospun nylon-6 fibers for biomedical applications
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Chitin butyrate coated electrospun nylon-6 fibers for biomedical applications

机译：用于生物医学应用的甲壳素丁酸酯涂层电纺尼龙6纤维

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摘要

In this study, we describe the preparation and characterizations of chitin butyrate (CB) coated nylon-6 nanofibers using single-spinneret electrospinning of blends solution. The physicochemical properties of nylon-6 composite fibers with different proportions of CB to nylon-6 were determined using FE-SEM, TEM, FT-1R spectroscopy, and water contact angle measurement. FE-SEM and TEM images revealed that the nylon-6 and CB were immiscible in the as-spun nanofibers, and phase separated nanofiber morphology becomes more pronounced with increasing amounts of CB. The bone formation ability of composite fibers was evaluated by incubating in biomimetic simulated body fluid. In order to assay the cytocompatibility and cell behavior on the composite scaffolds, osteoblast cells were seeded on the matrix. Results suggest that the deposition of CB layer on the surface of nylon-6 could increase its cell compatibility and bone formation ability. Therefore, as-synthesized nanocomposite fibrous mat has great potentiality in hard tissue engineering.
机译：在这项研究中，我们描述了使用单纺丝共混纺丝溶液纺丝的丁酸几丁质（CB）涂层尼龙6纳米纤维的制备和表征。使用FE-SEM，TEM，FT-1R光谱和水接触角测量，确定了CB与尼龙-6的比例不同的尼龙-6复合纤维的理化性质。 FE-SEM和TEM图像显示，尼龙6和CB在刚纺好的纳米纤维中是不溶混的，并且随着CB含量的增加，相分离的纳米纤维形态变得更加明显。通过在仿生模拟体液中孵育来评估复合纤维的骨形成能力。为了测定复合支架上的细胞相容性和细胞行为，将成骨细胞接种在基质上。结果表明，CB层在尼龙6表面的沉积可增加其细胞相容性和骨形成能力。因此，合成后的纳米复合纤维毡在硬组织工程中具有巨大的潜力。

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  • 来源
    《Applied Surface Science》 |2013年第ptab期|538-544|共7页
  • 作者

    Hem Raj Pant; Han Joo Kim; Lok Ranjan Bhatt; Mahesh Kumar Joshi; Eun Kyo Kim; Jeong In Kim; Abdalla Abdal-hay; K.S. Hui; Cheol Sang Kim;

  • 作者单位

    Department of Bio-nano System Engineering, Chonbuk National University, Jeonju 561-756, Republic of Korea,Department of Engineering Science and Humanities, Pulchowk Campus, Tribhuvan University, Kathmandu, Nepal;

    Division of Mechanical Design Engineering, Chonbuk National University, Jeonju 561-756, Republic of Korea;

    Nepal Academy of Science and Technology, Khumaltar, Lalitpur, Kathmandu, Nepal;

    Department of Bio-nano System Engineering, Chonbuk National University, Jeonju 561-756, Republic of Korea;

    Department of Bio-nano System Engineering, Chonbuk National University, Jeonju 561-756, Republic of Korea;

    Department of Bio-nano System Engineering, Chonbuk National University, Jeonju 561-756, Republic of Korea;

    Department of Bio-nano System Engineering, Chonbuk National University, Jeonju 561-756, Republic of Korea;

    Department of Mechanical Engineering, Hanyang University, 17 Haengdang-dong, Seongdong-gu, Seoul 133-791, Republic of Korea;

    Department of Bio-nano System Engineering, Chonbuk National University, Jeonju 561-756, Republic of Korea,Division of Mechanical Design Engineering, Chonbuk National University, Jeonju 561-756, Republic of Korea;

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  • 原文格式 PDF
  • 正文语种 eng
  • 中图分类
  • 关键词

    Nylon-6; Chitin butyrate; Nanofibers; Biomaterials; Electrospinning;

    机译：尼龙6;丁酸几丁质;纳米纤维;生物材料;静电纺丝;

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