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首页> 外文期刊>Applied Surface Science >Adsorption of Cathepsin B-sensitive peptide conjugated DOX on nanodiamonds
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Adsorption of Cathepsin B-sensitive peptide conjugated DOX on nanodiamonds

机译：组织蛋白酶B敏感肽共轭DOX在纳米金刚石上的吸附。

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摘要

Drug delivery mediated by nanodiamonds (NDs) has shown great promise in controlled drug release field. In present study, dipeptide (Phe-Lys) conjugated antitumor drug doxorubicin hydrochloride (DOX) with self-immolative p-aminobenzylcarbonyl (PABC) spacer was non-covalently bound to carboxylated NDs via the electrostatic interactions. HIV-1 trans-activating transcriptor peptide (TAT) was additionally integrated to this ND-based delivery system in order to enhance the transmembrane efficiency. Fourier transforms infrared spectroscopy (FTIR), transmission electron microscopy (TEM) and zeta potentials were applied to characterize the DOX and TAT loaded ND delivery platform. The adsorption equilibrium, kinetics and thermodynamics for the adsorption of peptide conjugated DOX onto NDs were investigated. It was found that the adsorption fitted well with the Freundlich model and conformed to pseudo-second order kinetics. It also showed that the adsorption was a spontaneous and exothermic process. Therefore, our work offered a facile way to formulate a ND-based drug delivery platform with multifunctionality in a layer by layer adsorption fashion.
机译：纳米金刚石（NDs）介导的药物递送在控释领域具有广阔的前景。在本研究中，二肽（Phe-Lys）结合的抗肿瘤药物阿霉素盐酸盐（DOX）与自消灭的对氨基苄基羰基（PABC）间隔物通过静电相互作用非共价结合到羧化NDs上。为了增强跨膜效率，还将HIV-1反式激活转录肽（TAT）整合到了这种基于ND的递送系统中。傅里叶变换红外光谱（FTIR），透射电子显微镜（TEM）和Zeta电位被用来表征DOX和TAT负载的ND传递平台。研究了肽共轭DOX在NDs上的吸附平衡，动力学和热力学。发现吸附与弗氏模型非常吻合，并符合拟二级动力学。还表明吸附是自发的并且放热的过程。因此，我们的工作提供了一种简便的方法，以逐层吸附的方式配制具有多功能的基于ND的药物递送平台。

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  • 来源
    《Applied Surface Science》 |2011年第20期|p.8617-8622|共6页
  • 作者

    Shanshan Huang; Jianqun Shao; Lifang Gao; Yingzhe Qi; Ling Ye;

  • 作者单位

    School of Chemical Biology and Pharmaceutical Sciences, Capital Medical University, Beijing 100069, PR China;

    School of Chemical Biology and Pharmaceutical Sciences, Capital Medical University, Beijing 100069, PR China;

    Center for Food and Drug Safety Evaluation of Capital Medical University, Beijing 100069, PR China;

    School of Chemical Biology and Pharmaceutical Sciences, Capital Medical University, Beijing 100069, PR China;

    School of Chemical Biology and Pharmaceutical Sciences, Capital Medical University, Beijing 100069, PR China;

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  • 原文格式 PDF
  • 正文语种 eng
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  • 关键词

    adsorption kinetics; adsorption thermodynamics; DOX; nanodiamonds; TAT;

    机译：吸附动力学吸附热力学DOX;纳米金刚石塔塔;

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