• 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Applied Surface Science >Use of quartz crystal nanobalance to study the binding and stabilization of albumin and doxycycline on a thin layer of hydroxyapatite
【24h】

Use of quartz crystal nanobalance to study the binding and stabilization of albumin and doxycycline on a thin layer of hydroxyapatite

机译：利用石英晶体纳米天平研究白蛋白和强力霉素在羟基磷灰石薄层上的结合和稳定性

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

This study reports the use of quartz crystal nanobalance (QCN) to study the adsorption of two model molecules namely albumin and doxycycline by hydroxyapatite (HA). The work focuses on the deposition of a stable coating of HA on the quartz crystal, modification of the coating using doxycycline and its subsequent effects on albumin adsorption. The uniformity and thickness of the HA coating has been studied using atomic force microscopy (AFM). The functional groups to ascertain the presence of the selected moieties have been characterized by Raman spectroscopy. The results indicate that the mass of albumin deposited on the surface of the HA coated quartz crystal functionalized with doxycycline shows a substantial increase when compared to the standard HA coated quartz crystal. The adsorbed albumin has also been found to be retained for an enhanced period of time. This surface immobilization of doxycycline and subsequent albumin adsorption seem to be a promising approach to confer biomaterials with antithrombogenic and antibacterial surfaces.
机译：这项研究报告了使用石英晶体纳米天平（QCN）研究羟基磷灰石（HA）对两种模型分子即白蛋白和强力霉素的吸附。这项工作的重点是在石英晶体上沉积稳定的HA涂层，使用强力霉素对涂层进行改性及其对白蛋白吸附的后续影响。 HA涂层的均匀性和厚度已使用原子力显微镜（AFM）进行了研究。确定所选部分的存在的官能团已通过拉曼光谱法表征。结果表明，与标准HA包被的石英晶体相比，沉积在用强力霉素功能化的HA包被的石英晶体表面上的白蛋白质量显示出明显的增加。还发现吸附的白蛋白可以保留更长的时间。强力霉素的这种表面固定和随后的白蛋白吸附似乎是赋予生物材料抗血栓形成和抗菌作用的一种有前途的方法。

著录项

  • 来源
    《Applied Surface Science》 |2011年第5期|p.1666-1669|共4页
  • 作者

    Sunita Prem Victor; Chandra P. Sharma; K. Sreenivasan;

  • 作者单位

    Biosurface Technology Division, Biomedical Technology Wing, Sree Chitra Tirunal Institute for Medical Sciences and Technology, Trivandrum 6950)2, Kerala, India;

    Biosurface Technology Division, Biomedical Technology Wing, Sree Chitra Tirunal Institute for Medical Sciences and Technology, Trivandrum 6950)2, Kerala, India;

    Biosurface Technology Division, Biomedical Technology Wing, Sree Chitra Tirunal Institute for Medical Sciences and Technology, Trivandrum 6950)2, Kerala, India,Laboratory for Polymer Analysis, Biomedical Technology Wing, Sree Chitra Tirunal Institute for Medical Sciences and Technology, Trivandrum 695012, Kerala, India;

  • 收录信息
  • 原文格式 PDF
  • 正文语种 eng
  • 中图分类
  • 关键词

    quartz crystal nanobalance; hydroxyapatite; albumin; doxycycline;

    机译：石英晶体纳米天平羟基磷灰石白蛋白;强力霉素;

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号