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Formation of amine groups on the surface of GaN: A method for direct biofunctionalization

机译：在GaN表面形成胺基的直接生物功能化方法

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Gallium nitride has attracted significant interest as a material for biosensors; however, techniques for biofunctionalizing GaN surfaces have received limited attention. Here, we present a method for producing amine groups directly on GaN surfaces through exposure to a glow discharge plasma fed with humidified air, thereby eliminating the need for complex organic functionalization chemistry. Amine formation is tracked via X-ray photoelectron spectroscopy (XPS) by labeling the plasma-formed surface groups with a fluorinated probe that binds specifically to primary amines. These amine groups can subsequently couple covalently to a wide range of biomolecules. The covalent immobilization of a NeutrAvidin layer is demonstrated using Fourier transform infrared spectroscopy (FT-IR) and fluorescent biotin-binding assays. Finally, we show that plasma exposure times sufficient for the formation of amine groups do not significantly alter the conductivity of the GaN substrate.
机译：氮化镓作为生物传感器的材料引起了广泛的兴趣。然而，将GaN表面生物功能化的技术受到了有限的关注。在这里，我们介绍了一种通过暴露在加有空气的辉光放电等离子体中直接在GaN表面产生胺基的方法，从而消除了对复杂有机功能化化学物质的需求。通过X射线光电子能谱（XPS）来跟踪胺的形成，方法是用一种与伯胺特异性结合的氟化探针标记等离子体形成的表面基团。这些胺基团随后可以共价偶联至广泛的生物分子。使用傅立叶变换红外光谱（FT-IR）和荧光生物素结合测定法证明NeutrAvidin层的共价固定化。最后，我们表明足以形成胺基的等离子体暴露时间不会显着改变GaN衬底的电导率。

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