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首页> 外文期刊>Applied Surface Science >Naproxen drug delivery using periodic mesoporous silica SBA-15
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Naproxen drug delivery using periodic mesoporous silica SBA-15

机译：使用定期中孔二氧化硅SBA-15的萘普生药物递送

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摘要

In this paper, we present the release of naproxen from hexagonal periodic mesoporous silica SBA-15, which serves as a drug delivery system. Naproxen, the well-known nonsteroidal anti-inflammatory drug (NSAID), was loaded into the pores of SBA-15 silica modified with aminopropyl groups. The physic-ochemical properties of the modified sample (A-SBA-15apro) were compared with the unmodified SBA-15 mesoporous silica loaded with the drug (SBA-15apro). The kinetic of the naproxen release into the physiological solution was studied. The released amount of naproxen represented 90.7% from the unmodified SBA-15 in 72 h, while from the sample A-SBA-15apro the released amount represented about 80.9%. The prepared materials were characterized by nitrogen adsorption/desorption, Small angle X-ray scattering (SAXS), Fourier-transform infrared spectroscopy (FT-IR) and the thermoanalytical methods (TG/DTA). Thin layer chromatography (TLC) was used for quantitative determination of the released naproxen.
机译：在本文中，我们介绍了萘普生从六角形周期性介孔二氧化硅SBA-15中的释放，该药物可作为药物输送系统。将萘普生（一种著名的非甾体类抗炎药（NSAID））装入经过氨基丙基修饰的SBA-15二氧化硅的孔中。将改性样品（A-SBA-15 / napro）的理化性质与负载了该药物的未改性SBA-15中孔二氧化硅（SBA-15 / napro）进行了比较。研究了萘普生释放到生理溶液中的动力学。萘普生的释放量占72小时内未修饰SBA-15的90.7％，而样品A-SBA-15 / napro的释放量约为80.9％。所制备的材料通过氮吸附/解吸，小角度X射线散射（SAXS），傅立叶变换红外光谱（FT-IR）和热分析方法（TG / DTA）进行表征。薄层色谱法（TLC）用于定量测定释放的萘普生。

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  • 来源
    《Applied Surface Science》 |2010年第22期|p.6489-6494|共6页
  • 作者

    Dasa Halamova; Maria Badanicova; Vladimir Zelenak; Tatana Gondova; Ulla Vainio;

  • 作者单位

    Department of Inorganic Chemistry Faculty of Science, P.J. Safarik University, Moyzesova 11, SK-041 54 KoSice, Slovak Republic;

    Department of Inorganic Chemistry Faculty of Science, P.J. Safarik University, Moyzesova 11, SK-041 54 KoSice, Slovak Republic;

    Department of Inorganic Chemistry Faculty of Science, P.J. Safarik University, Moyzesova 11, SK-041 54 KoSice, Slovak Republic;

    Department of Analytical Chemistry Faculty of Science, P.J. Safarik University, Moyzesova 17, SK-041 54 Koike, Slovak Republic;

    Hasylab, DESY, Notkestrasse 85, Hamburg, Germany;

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  • 原文格式 PDF
  • 正文语种 eng
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  • 关键词

    mesoporous silica; naproxen; controlled release; drug delivery;

    机译：介孔二氧化硅萘普生控释;药物输送;

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