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Preparation And Anti-tumor Evaluation Of Polyactin A Microparticles From Supercritical Co_2 Processing

机译：超临界Co_2处理聚肌动蛋白A微粒的制备及抗肿瘤评价

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摘要

This paper reports the use of a coating process based on supercritical fluid technology to prepare a solvent-free microparticles, loaded with a polymannopeptide (polyactin A, PAA) for enhancing optimal host response in cancer immunotherapy. Microparticles were characterized as regards their morphology, drug content and in vitro release. A prolonged release of the PAA had been achieved over a 24 h period from microparticles coated with the lipidic compound, which produced a more homogeneous, film-forming coating. Furthermore, it was shown that PAA did not undergo any degradation under the supercritical conditions used in the coating process. In vitro immunoactivity and anti-tumor effect analysis results showed that the PAA microparticle could efficiently trigger the induction of cytotoxic T lymphocytes (CTLs) in a sustained manner.
机译：本文报道了基于超临界流体技术的包衣工艺制备无溶剂的微粒的过程，该微粒载有聚甘露肽（聚肌动蛋白A，PAA），可增强癌症免疫治疗中的最佳宿主反应。表征微粒的形态，药物含量和体外释放。在24小时内，由涂有脂质化合物的微粒实现了PAA的延长释放，从而产生了更均匀的成膜涂层。此外，表明在涂覆过程中使用的超临界条件下，PAA不会发生任何降解。体外免疫活性和抗肿瘤作用分析结果表明，PAA微粒可以持续有效地触发细胞毒性T淋巴细胞（CTL）的诱导。

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