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Chondroitin Sulfate Template-mediated Biomimetic Synthesis Of Nano-flake Hydroxyapatite

机译:硫酸软骨素模板介导的仿生片状羟基磷灰石仿生合成

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摘要

By Ca(NO_3)_2-4H_2O and (NH_4)_3PO_4· 3H_2O as reagents and chondroitin sulfate (ChS) as a template, nano-flake hydroxyapatite (HA) is synthesized using a biomimetic method according to the biomineralization theory. HA crystals obtained are characterized in crystalline phase, microstructure, chemical composition and morphology by X-ray diffraction (XRD), Fourier transform infrared spectroscope (FTIR), transmission electron microscopy (TEM) and elemental analysis respectively. UV-vis spectrum is adopted to investigate interactions between functional groups ChS and HA. The results show that HA crystal nucleation and growth take place in chemical interactions between HA crystals and ChS as a template. And elemental analysis indicates that obtained HA contains a small amount of ChS. Furthermore, ChS concentration significantly affects the morphology of HA crystals. Staple-fiber-like HA crystals can be obtained at a low concentration in ChS, and flake-like HA crystals synthesized at a high concentration (≥0.5 wt.%) of ChS as a template.
机译:以Ca(NO_3)_2-4H_2O和(NH_4)_3PO_4·3H_2O为试剂,硫酸软骨素(ChS)为模板,根据生物矿化理论,采用仿生法合成了纳米片状羟基磷灰石(HA)。分别通过X射线衍射(XRD),傅立叶变换红外光谱仪(FTIR),透射电子显微镜(TEM)和元素分析对所得的HA晶体的结晶相,微观结构,化学组成和形态进行表征。采用紫外可见光谱研究官能团ChS和HA之间的相互作用。结果表明HA晶体成核和生长发生在HA晶体和ChS作为模板之间的化学相互作用中。元素分析表明,所获得的HA含有少量的ChS。此外,ChS浓度显着影响HA晶体的形态。可以在ChS中以低浓度获得短纤维状HA晶体,并以ChS的高浓度(≥0.5wt。%)合成的片状HA晶体作为模板。

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