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首页> 外文期刊>Applied Surface Science >Surface Modification With Both Phosphorylcholine And Stearyl Groups To Adjust Hydrophilicity And Hydrophobicity
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Surface Modification With Both Phosphorylcholine And Stearyl Groups To Adjust Hydrophilicity And Hydrophobicity

机译：用磷酸胆碱和硬脂基进行表面改性以调节亲水性和疏水性

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摘要

A new monolayer film with tunable hydrophilicity and hydrophobicity was constructed on glass coverslips by stepwise grafting with both phosphorylcholine (PC) and stearyl groups. The glass coverslips were firstly hydroxylized to provide reactive sites on the surfaces. Subsequently, chlorodimethyl-n-octadecylsilane was chemically adsorbed onto the surface to impart the required hydrophobicity. The remaining hydroxyl groups were grafted with 1,6-diisocyanatohexane. Finally, 2-hydroxy-2-ethylpho-sphorylcholine was grafted onto the attached isocyanate groups. Dynamic contact angle (DCA) measurement and X-ray photoelectron spectroscopy (XPS) analysis confirmed that the step-by-step modification process was successful. The adsorption of bovine serum albumin and bovine plasma fibrinogen, as well as the adhesion and aggregation of platelets were suppressed with the introduction of phospholipid moieties on the surfaces. This tunable surface may have potential applications in the fields of separation science, tissue engineering, cytobiology, drug delivery and gene therapy.
机译：通过逐步接枝磷酸胆碱（PC）和硬脂基，在玻璃盖玻片上构建了具有可调亲水性和疏水性的新型单层膜。首先将玻璃盖玻片羟基化以在表面上提供反应部位。随后，将氯二甲基-正十八烷基硅烷化学吸附到表面上以赋予所需的疏水性。剩余的羟基接枝有1，6-二异氰酸根合己烷。最后，将2-羟基-2-乙基膦基胆碱接枝到连接的异氰酸酯基团上。动态接触角（DCA）测量和X射线光电子能谱（XPS）分析证实，逐步修饰过程是成功的。通过在表面上引入磷脂部分，抑制了牛血清白蛋白和牛血浆纤维蛋白原的吸附以及血小板的粘附和聚集。这种可调表面可能在分离科学，组织工程，细胞生物学，药物递送和基因治疗领域具有潜在的应用。

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