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首页> 外文期刊>Applied Surface Science >Investigation Of The Cosmetic Ingredient Distribution In The Stratum Corneum Using Nanosims Imaging
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Investigation Of The Cosmetic Ingredient Distribution In The Stratum Corneum Using Nanosims Imaging

机译：用Nanosims成像技术研究角质层化妆品成分的分布

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摘要

In order to understand the mechanisms of action of cosmetic ingredients, it is important to establish the distribution of the component agents within the epidermis of the skin. To date, time-of-flight secondary ion mass spectrometry (TOF-SIMS) has been used to detect cosmetic ingredients in the skin. However, it is technically difficult to investigate the distribution of the agents in the stratum corneum using TOF-SIMS. Therefore, an analytical method with higher spatial resolution is required. In this study, we investigated an imaging analysis technique based on NanoSIMS to detect cosmetic ingredients in the skin. Pig skin was used as a model for human skin. The sample was treated with a cosmetic formulation containing ~(15)N-labelled pseudo-ceramide (SLE). The sample was frozen with liquid nitrogen and cross-sections were cut using a cryomicrotome. As a result, the fine layer structure of the corneocytes was clearly observed by using NanoSIMS. Our studies indicate that SLE penetrates into the stratum corneum via an intercellular route. We conclude that application of NanoSIMS analysis can contribute to a better understanding of the function of cosmetic ingredients in the skin.
机译：为了理解化妆品成分的作用机理，重要的是建立成分剂在皮肤表皮内的分布。迄今为止，飞行时间二次离子质谱法（TOF-SIMS）已用于检测皮肤中的化妆品成分。然而，使用TOF-SIMS研究在角质层中药物的分布在技术上是困难的。因此，需要一种具有更高空间分辨率的分析方法。在这项研究中，我们研究了一种基于NanoSIMS的成像分析技术，可检测皮肤中的化妆品成分。猪皮被用作人类皮肤的模型。样品用含有〜（15）N标记的假神经酰胺（SLE）的化妆品制剂处理。用液氮冷冻样品，并使用冷冻切片机切开横截面。结果，通过使用NanoSIMS清楚地观察到了角质细胞的精细层结构。我们的研究表明SLE通过细胞间途径渗透到角质层。我们得出的结论是，NanoSIMS分析的应用可以有助于更好地理解皮肤中化妆品成分的功能。

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