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首页> 外文期刊>Applied Surface Science >Interaction between α-actinin and negatively charged lipids membrane investigated by surface plasmon resonance and electrochemical methods
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Interaction between α-actinin and negatively charged lipids membrane investigated by surface plasmon resonance and electrochemical methods

机译：表面等离振子共振和电化学方法研究α-肌动蛋白与带负电荷的脂质膜之间的相互作用

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摘要

α-Actinin has been shown to be capable of interacting with some special membrane phospholipids directly, which is important for its function. In this study, hybrid bilayer membranes composed of negatively charged lipids are constructed on the surface plasmon resonance gold substrate and on the gold electrode, respectively, and the interaction between a-actinin and negatively charged lipids membrane is investigated by surface plasmon resonance, cyclic voltammetry and electrochemical impedance spectroscopy methods. α-Actinin is proved to be able to interact with the negatively charged lipids membrane directly. It can also insert at least partly into the membrane or lead to some defect or lesion in the membrane, which increase the permeability of the membrane. This study would bring some insight on the interaction between the α-actinin and the cell membranes in vivo.
机译：已经证明α-肌动蛋白能够与某些特殊的膜磷脂直接相互作用，这对其功能很重要。在这项研究中，分别在表面等离振子共振金基底和金电极上构建了由带负电的脂质组成的混合双层膜，并通过表面等离振子共振，循环伏安法研究了α-肌动蛋白与带负电的脂质膜之间的相互作用。和电化学阻抗谱方法。已证明α-肌动蛋白可以直接与带负电荷的脂质膜相互作用。它也可以至少部分插入膜中或导致膜中的某些缺陷或病变，这增加了膜的渗透性。这项研究将为体内α-肌动蛋白与细胞膜之间的相互作用带来一些见识。

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