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Characterization of drug-eluting stent (DES) materials with cluster secondary ion mass spectrometry (SIMS)

机译：簇二次离子质谱（SIMS）表征药物洗脱支架（DES）材料

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Secondary ion mass spectrometry (SIMS) employing an SF5+ polyatomic primary ion source was utilized to analyze several materials commonly used in drug-eluting stents (DES). Poly(ethylene-co-vinyl acetate) (PEVA), poly(lactic-co-glycolic acid) (PLGA) and various poly(urethanes) were successfully depth profiled using SF5+ bombardment. The resultant molecular depth profiles obtained from these polymeric films showed very little degradation in molecular signal as a function of increasing SF5+ primary ion dose when experiments were performed at low temperatures (signal was maintained for doses up to similar to 5 x 10(15) ions/cm(2)). Temperature was determined to be an important parameter in both the success of the depth profiles and the mass spectral analysis of the polymers. In addition to the pristine polymer films, paclitaxel (drug released in Taxus (TM) stent) containing PLGA films were also characterized, where it was confirmed that both drug and polymer signals could be monitored as a function of depth at lower paclitaxel concentrations (10 wt%). Published by Elsevier B.V.
机译：利用SF5 +多原子一次离子源的二次离子质谱（SIMS）被用于分析药物洗脱支架（DES）中常用的几种材料。使用SF5 +轰击成功地对聚（乙烯-乙酸乙烯酯共聚物）（PEVA），聚乳酸-乙醇酸共聚物（PLGA）和各种聚氨基甲酸酯进行了深度剖析。当在低温下进行实验时，从这些聚合物薄膜获得的分子深度分布图显示出分子信号几乎没有随SF5 +初级离子剂量增加而降低的信号降解（信号的剂量维持至接近5 x 10（15）离子） / cm（2））。确定温度是成功进行深度分布和聚合物质谱分析的重要参数。除原始的聚合物薄膜外，还对包含PLGA薄膜的紫杉醇（在Taxus（TM）支架中释放的药物）进行了表征，已证实在较低的紫杉醇浓度下，药物和聚合物信号均可作为深度的函数进行监测（10 wt％）。由Elsevier B.V.发布

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