Analysis of cardiac tissue by gold cluster ion bombardment

Aranyosiova M; Chorvatova A; Chorvat D; Biro C; Velic D

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Analysis of cardiac tissue by gold cluster ion bombardment

机译：金簇离子轰击法分析心脏组织

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Specific molecules in cardiac tissue of spontaneously hypertensive rats are studied by using time-of-flight secondary ion mass spectrometry (TOF-SIMS). The investigation determines phospholipids, cholesterol, fatty acids and their fragments in the cardiac tissue, with special focus on cardiolipin. Cardiolipin is a unique phospholipid typical for cardiornyocyte mitochondrial membrane and its decrease is involved in pathologic conditions. In the positive polarity, the fragments of phosphalydilcholine are observed in the mass region of 700-850 u. Peaks over mass 1400 u correspond to intact and cationized molecules of cardiolipin. In animal tissue, cardiolipin contains of almost exclusively 18 carbon fatty acids, mostly linoleic acid. Linoleic acid at 279 u, other fatty acids, and phosphatidylglycerol fragments, as precursors of cardiolipin synthesis, are identified in the negative polarity. These data demonstrate that SIMS technique along with Au-3(+) cluster primary ion beam is a good tool for detection of higher mass biomolecules providing approximately 10 times higher yield in comparison with Au+. (c) 2006 Elsevier B.V. All rights reserved.

机译：通过飞行时间二次离子质谱（TOF-SIMS）研究自发性高血压大鼠心脏组织中的特定分子。该研究确定了心脏组织中的磷脂，胆固醇，脂肪酸及其片段，特别是心磷脂。心磷脂是典型的心肌细胞线粒体膜独特的磷脂，其减少与病理状况有关。在正极，在700-850 u的质量区域中观察到了磷酰胆碱的碎片。质量1400 u以上的峰对应于完整的和阳离子化的心磷脂分子。在动物组织中，心磷脂几乎只包含18种碳脂肪酸，主要是亚油酸。 279 u的亚油酸，其他脂肪酸和磷脂酰甘油片段作为心磷脂合成的前体，被鉴定为负极性。这些数据表明，SIMS技术与Au-3（+）团簇主离子束一起是检测更高质量的生物分子的良好工具，与Au +相比，其产率高出约10倍。（c）2006 Elsevier B.V.保留所有权利。

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《Applied Surface Science》 |2006年第19期|p. 6782-6785|共4页
作者
Aranyosiova M; Chorvatova A; Chorvat D; Biro C; Velic D;
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作者单位

Ctr Int Laser, SK-81219 Bratislava, Slovakia;

Comenius Univ, Fac Nat Sci, SK-84215 Bratislava, Slovakia;

Hop St Justine, Res Ctr, Montreal, PQ H3T 1C5, Canada;

Comenius Univ, Fac Math Phys & Informat, SK-84215 Bratislava, Slovakia;

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正文语种 eng
中图分类应用物理学;
关键词
TOF-SIMS; cardiac tissue; cardiolipin; Au-3(+) cluster primary ions; MASS-SPECTROMETRY; TOF-SIMS; CARDIOLIPIN; LIPIDS; CELLS;

机译：TOF-SIMS;心脏组织;心磷脂;Au-3（+）簇初级离子;质谱法;TOF-SIMS;加地平;脂质;细胞;

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专利

1. Tissue Molecular Ion Imaging by Gold Cluster Ion Bombardment [J] . David Touboul, Frederic Halgand, Alain Brunelle, Analytical chemistry . 2004,第6期

机译：金簇离子轰击对组织分子离子成像
2. Simulation of Desorption of Gold Nanoclusters Deposited on the (111) Surface of Al and Au under Bombardment with Au_1 Ions and Au_(400) Clusters Using the Classical Molecular Dynamics Method [J] . E. E. Zhurkin Journal of surface investigation: x-ray, synchrotron and neutron techniques . 2010,第2期

机译：用经典分子动力学方法模拟Au_1离子和Au_（400）团簇轰击沉积在Al和Au（111）表面的金纳米团簇的解吸
3. Sputtering and emission of nanoclusters under bombardment of gold nanodispersed targets by 1 MeV Au-5 cluster ions [J] . Baranov I, Della-Negra S, Fallavier M, Nuclear Instruments & Methods in Physics Research. B, Beam Interactions with Materials and Atoms . 2006,第1期

机译：1 MeV Au-5团簇离子轰击金纳米分散靶标下的纳米团簇的溅射和发射
4. Gold nanoparticle loaded porcine cholecystic-extracellular matrix: A potential bioscaffold for cardiac tissue engineering [C] . Reshma Sukumaran Nair, Anilkumar TV World biomaterials congress . 2016

机译：载有金纳米颗粒的猪胆囊外细胞基质：用于心脏组织工程的潜在生物支架
5. Advanced instrumental techniques: (1) Analysis of spatial chemical phase segregation in biodegradable polymers by STXM and TOF-SIMS (2) Novel effects of cluster vs. monatomic primary ion bombardment of polymers in TOF-SIMS. [D] . Wells, David D. 2010

机译：先进的仪器技术：（1）通过STXM和TOF-SIMS分析可生物降解聚合物中的空间化学相偏析（2）在TOF-SIMS中，聚合物对单原子主离子轰击的新作用。
6. Self-Assembled Gold Nano-Ripple Formation by Gas Cluster Ion Beam Bombardment [O] . Buddhi P. Tilakaratne, Quark Y. Chen, Wei-Kan Chu 2017

机译：气体团簇离子束轰击自组装形成金纳米波纹
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8. Determination of Gold Accumulation in Human Tissues Caused by Gold Therapy Using X-Ray Fluorescence Analysis [R] . 1986

机译：用X射线荧光分析法测定金疗法引起的人体组织中金的积累

Analysis of cardiac tissue by gold cluster ion bombardment

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